ArticleJournal of neurology2008
Neuroleptic-induced parkinsonism is associated with olfactory dysfunction.
Article in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Comparative Olfactory Profiles in Parkinson's Disease and Drug-Induced Parkinsonism.Journal of movement disorders · 2024Article
- Towards an understanding of the pathological basis of senile depression and incident dementia: Implications for treatment.Psychiatry and clinical neurosciences · 2022Review
- Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?Nature reviews. Neuroscience · 2022Review
- Recognition and Management of Antipsychotic-Induced Parkinsonism in Older Adults: A Narrative Review.Medicines (Basel, Switzerland) · 2021Review
- From passive overeating to "food addiction": a spectrum of compulsion and severity.ISRN obesity · 2013Review
- Olfactory dysfunction: common in later life and early warning of neurodegenerative disease.Deutsches Arzteblatt international · 2013Review
- Drug-induced parkinsonism in the elderly: incidence, management and prevention.Drugs & aging · 2012Review
- Olfactory loss in Parkinson's disease.Parkinson's disease · 2011Article
- The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism.Journal of neurology · 2010Article
- Article
- Olfactory Impairment Predicts Underlying Dopaminergic Deficit in Presumed Drug-Induced Parkinsonism.Movement disorders clinical practiceArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere is increasing evidence for olfactory deficits in patients with extrapyramidal disorders, but little is known about their occurrence in patients with drug-induced extrapyramidal symptoms (EPS). The present study was performed to investigate olfactory function in depressed patients with drug-induced parkinsonism under treatment with D2-blocking neuroleptic drugs compared to depressed controls on similar neuroleptic dose without EPS (no-EPS), and neuroleptic-naive depressed controls (no-NL).
methodsA total of 79 depressed patients with (N = 59) and without psychotic features (N = 20) were included in the study. Psychotic patients were treated with D2 blocking neuroleptic drugs. Of the neuroleptic-treated patients, 15 developed EPS. In all patients psychophysical olfactory testing was performed using "Sniffin' Sticks" which included assessment of odor thresholds for phenylethylalcohol (PEA), odor identification, and odor discrimination.
resultsPatients in the EPS group had significantly lower olfactory scores than patients in the no-EPS or no-NL groups. Patients in the no-NL and no-EPS groups were not significantly different from each other in terms of olfactory function. Using partial correlations controlling for the patients' age, significant correlations were observed for EPS patients between severity of EPS and odor thresholds and odor identification, but not for odor discrimination. This indicated that olfactory function decreased with increasing severity of EPS symptoms.
conclusionsOur data show that olfactory deficits may be drug-induced in patients with primary affective disorder with a sensitivity toward developing EPS.
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