ArticlePloS one2008
Development and Notch signaling requirements of the zebrafish choroid plexus.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Single-Cell-Resolution Fate Mapping Reveals Embryonic Venous Origins of Fenestrated Hindbrain Choroid Plexus Vasculature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reproducibility and transparency: why following MISEV guidelines is beneficial for the studies on EVs and brain barriers.Extracellular vesicles and circulating nucleic acids · 2025Article
- Homemade: building the structure of the neurogenic niche.Frontiers in cell and developmental biology · 2023Review
- Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier.Fluids and barriers of the CNS · 2022Article
- Experimental approaches for manipulating choroid plexus epithelial cells.Fluids and barriers of the CNS · 2022Review
- Regulation of choroid plexus development and its functions.Cellular and molecular life sciences : CMLS · 2022Review
- The Wilms Tumor GeneFrontiers in cell and developmental biology · 2021Article
- Developmental Angiogenesis Requires the Mitochondrial Phenylalanyl-tRNA Synthetase.Frontiers in cardiovascular medicine · 2021Article
- Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.Cell death and differentiation · 2019Article
- A transgenic zebrafish model for theBiology open · 2018Article
- Development of brain ventricular system.Cellular and molecular life sciences : CMLS · 2018Review
- Development of Circumventricular Organs in the Mirror of Zebrafish Enhancer-Trap Transgenics.Frontiers in neuroanatomy · 2017Article
- Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.Nature cell biology · 2016Article
- Development and functions of the choroid plexus-cerebrospinal fluid system.Nature reviews. Neuroscience · 2015Review
- Choroid plexus in developmental and evolutionary perspective.Frontiers in neuroscience · 2014Review
- Functional and genetic analysis of choroid plexus development in zebrafish.Frontiers in neuroscience · 2014Article
- The choroid plexuses and their impact on developmental neurogenesis.Frontiers in neuroscience · 2014Review
- Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis.Developmental biology · 2012Article
- The roof plate boundary is a bi-directional organiser of dorsal neural tube and choroid plexus development.Development (Cambridge, England) · 2012Article
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe choroid plexus (CP) is an epithelial and vascular structure in the ventricular system of the brain that is a critical part of the blood-brain barrier. The CP has two primary functions, 1) to produce and regulate components of the cerebral spinal fluid, and 2) to inhibit entry into the brain of exogenous substances. Despite its importance in neurobiology, little is known about how this structure forms. METHODOLOGY AND PRINCIPAL
findingsHere we show that the transposon-mediated enhancer trap zebrafish line Et(Mn16) expresses green fluorescent protein within a population of cells that migrate toward the midline and coalesce to form the definitive CP. We further demonstrate the development of the integral vascular network of the definitive CP. Utilizing pharmacologic pan-notch inhibition and specific morpholino-mediated knockdown, we demonstrate a requirement for Notch signaling in choroid plexus development. We identify three Notch signaling pathway members as mediating this effect, notch1b, deltaA, and deltaD. CONCLUSIONS AND SIGNIFICANCE: This work is the first to identify the zebrafish choroid plexus and to characterize its epithelial and vasculature integration. This study, in the context of other comparative anatomical studies, strongly indicates a conserved mechanism for development of the CP. Finally, we characterize a requirement for Notch signaling in the developing CP. This establishes the zebrafish CP as an important new system for the determination of key signaling pathways in the formation of this essential component of the vertebrate brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.