ArticlePloS one2008
A natural human retrovirus efficiently complements vectors based on murine leukemia virus.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- The role of polo-like kinase 3 in the response of BRAF-mutant cells to targeted anticancer therapies.Molecular carcinogenesis · 2020Article
- P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.Molecular carcinogenesis · 2017Article
- Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.The Journal of clinical investigation · 2016Article
- MicroRNA analysis suggests an additional level of feedback regulation in the NF-κB signaling cascade.Oncotarget · 2015Article
- Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment.Cell cycle (Georgetown, Tex.) · 2014Article
- Utilization of replication-competent XMRV reporter-viruses reveals severe viral restriction in primary human cells.PloS one · 2013Article
- XMRV induces cell migration, cytokine expression and tumor angiogenesis: are 22Rv1 cells a suitable prostate cancer model?PloS one · 2012Article
- Xenotropic murine leukemia virus-related virus (XMRV) in prostate cancer cells likely represents a laboratory artifact.Oncotarget · 2011Article
- Long-distance effects of insertional mutagenesis.PloS one · 2011Article
- No evidence for XMRV association in pediatric idiopathic diseases in France.Retrovirology · 2010Article
- The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.Nature reviews. Urology · 2010Review
- Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Virology. A new virus for old diseases?Science (New York, N.Y.) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMurine Leukemia Virus (MLV) is a rodent gammaretrovirus that serves as the backbone for common gene delivery tools designed for experimental and therapeutic applications. Recently, an infectious gammaretrovirus designated XMRV has been identified in prostate cancer patients. The similarity between the MLV and XMRV genomes suggests a possibility that the two viruses may interact when present in the same cell. METHODOLOGY/PRINCIPAL
findingsWe tested the ability of XMRV to complement replication-deficient MLV vectors upon co-infection of cultured human cells. We observed that XMRV can facilitate the spread of these vectors from infected to uninfected cells. This functional complementation occurred without any gross rearrangements in the vector structure, and the co-infected cells produced as many as 10(4) infectious vector particles per milliliter of culture medium. CONCLUSIONS/SIGNIFICANCE: The possibility of encountering a helper virus when delivering MLV-based vectors to human cells in vitro and in vivo needs to be considered to ensure the safety of such procedures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.