ArticleMediators of inflammation2008
The NALP3/Cryopyrin-inflammasome complex is expressed in LPS-induced ocular inflammation.
Article in Mediators of inflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the current efforts to develop brain-penetrant inhibitors.Advances in pharmacology (San Diego, Calif.) · 2025Review
- Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production.Scientific reports · 2016Article
- Allergic airway inflammation by nasal inoculation of particulate matter (PM2.5) in NC/Nga mice.PloS one · 2014Article
- Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells.PloS one · 2013Article
- The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Polymorphisms in inflammasome genes and risk of coal workers' pneumoconiosis in a Chinese population.PloS one · 2012Article
- Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver.World journal of gastroenterology · 2011Article
- NLRs in immune privileged sites.Current opinion in pharmacology · 2011Review
- An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors.Journal of molecular medicine (Berlin, Germany) · 2009Review
- The inflammasome pathway: A key player in ocular surface and anterior segment diseases.Survey of ophthalmologyReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the inflammosome complex, NALP3 or NALP1 binds to ASC and activates caspase-1 which induces IL-1beta. In murine LPS-induced ocular inflammation, the production of IL-1beta is increased. We suggest that NALP3- or NALP1-inflammasome complex can be participating in the LPS-induced ocular inflammation. In this work, eye, brain, testis, heart, spleen, and lung were obtained from C3H/HeN mice treated with LPS for 3 to 48 hours, and the expression of NALP1b, NALP3, ASC, caspase-1, IL-1beta, and IL-18 was determined. Infiltrated leukocytes producing IL-1beta in the anterior chamber were found at 12-hour posttreatment. A high upregulated expression of NALP3, ASC, caspase-1, IL-1beta, and IL-18 was found at the same time when infiltrated leukocytes were observed. NALP1b was not detected in the eye of treated mice. NALP3 was also overexpressed in heart and lung. These results suggest that NALP3-, but not NALP1-inflammosome complex, is participating in the murine LPS-induced ocular inflammation.
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