ReviewJournal of perinatology : official journal of the California Perinatal Association2009
Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03291496 (Microfluidic Assessment of Clinical Outcomes in Preterm Newborns), which is not on this map. Cited by 52 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Microfluidic Assessment of Clinical Outcomes in Preterm Newborns
Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Predictors of extubation failure in newborns: a systematic review and meta-analysis.Italian journal of pediatrics · 2023Pooled it
- Pooled it
- Use of C-reactive protein to tailor antibiotic use: a systematic review and meta-analysis.BMJ open · 2018Pooled it
- IL-27 neutralization with and without antibiotics as an approach to prevent and treat neonatal sepsis.JCI insight · 2026Article
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- CpG-oligodeoxynucleotides challenged macrophages ameliorate acetaminophen induced liver injury by activating TLR9/IRG1/itaconate metabolic pathway.Molecular medicine (Cambridge, Mass.) · 2025Article
- Neonatal Sepsis: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2024Review
- Development and validation of a novel risk classification tool for predicting long length of stay in NICU blood transfusion infants.Scientific reports · 2024Article
- Risk factors for length of NICU stay of newborns: A systematic review.Frontiers in pediatrics · 2023Review
- Sex differences in neonatal brain injury and inflammation.Frontiers in immunology · 2023Review
- Clinical impact of NEC-associated sepsis on outcomes in preterm infants.Pediatric research · 2022Article
- Reelin cells and sex-dependent synaptopathology in autism following postnatal immune activation.British journal of pharmacology · 2022Article
- Knowledge gaps in late-onset neonatal sepsis in preterm neonates: a roadmap for future research.Pediatric research · 2022Review
- Protective Role of an Initial Low-Dose Septic Challenge against Lethal Sepsis in Neonatal Mice: A Pilot Study.Journal of clinical medicine · 2021Article
- Comparison of Interleukin-6 Plasma Concentration in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Pediatric Sepsis.Frontiers in pediatrics · 2021Article
- Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis.Shock (Augusta, Ga.) · 2020Review
- Hospital-acquired Enterobacteriaceae bloodstream infections in children.Developmental period medicine · 2019Review
- Neonatal intestinal dysbiosis in necrotizing enterocolitis.Molecular medicine (Cambridge, Mass.) · 2018Review
- Activation of Invariant Natural Killer T Cells Redirects the Inflammatory Response in Neonatal Sepsis.Frontiers in immunology · 2018Article
- Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis.Frontiers in immunology · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Prevention of neonatal infection-related mortality represents a significant global challenge particularly in the vulnerable premature population. The increased risk of death from sepsis is likely due to the specific immune deficits found in the neonate as compared to the adult. Stimulation of the neonatal immune system to prevent and/or treat infection has been attempted in the past largely without success. In this review, we identify some of the known deficits in the neonatal immune system and their clinical impact, summarize previous attempts at immunomodulation and the outcomes of these interventions, and discuss the potential of novel immunomodulatory therapies to improve neonatal sepsis outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.