Trial reportJournal of acquired immune deficiency syndromes (1999)2008
Episodic antiretroviral therapy increases HIV transmission risk compared with continuous therapy: results of a randomized controlled trial.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Behavioral interventions to promote condom use among women living with HIV.The Cochrane database of systematic reviews · 2011Pooled it
- Participant Perspectives and Experiences Following an Intensively Monitored Antiretroviral Pause in the United States: Results from the AIDS Clinical Trials Group A5345 Biomarker Study.AIDS research and human retroviruses · 2022Trial
- Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison.AIDS (London, England) · 2019Trial
- Transmission risk behaviour at enrolment in participants in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.HIV medicine · 2015Trial
- Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection.PloS one · 2012Trial
- Virological Outcome Measures During Analytical Treatment Interruptions in Chronic HIV-1-Infected Patients.Open forum infectious diseases · 2019Article
- Sexual behaviour among people with HIV according to self-reported antiretroviral treatment and viral load status.AIDS (London, England) · 2016Article
- Evaluating the efficacy of therapeutic HIV vaccines through analytical treatment interruptions.Journal of the International AIDS Society · 2015Review
- The ethics of HIV "cure" research: what can we learn from consent forms?AIDS research and human retroviruses · 2015Article
- Antiretroviral treatment interruption and loss to follow-up in two HIV cohorts in Australia and Asia: implications for 'test and treat' prevention strategy.AIDS patient care and STDs · 2013Article
- Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV Cohort Study.PloS one · 2013Article
- The 'Antiretrovirals, Sexual Transmission Risk and Attitudes' (ASTRA) study. Design, methods and participant characteristics.PloS one · 2013Article
- The Impact of Health Insurance Policy Changes on Californians with Severe Chronic Disease.California journal of politics and policy · 2011Article
- Universal testing and treatment as an HIV prevention strategy: research questions and methods.Current HIV research · 2011Review
- HIV Treatment in the Criminal Justice System: Critical Knowledge and Intervention Gaps.AIDS research and treatment · 2011Article
- Comparisons of sexual behaviors and STD prevalence among older and younger individuals with HIV infection.AIDS care · 2010Article
- The impact of antiretroviral therapy in a cohort of HIV infected patients going in and out of the San Francisco county jail.PloS one · 2009Article
- Health Utility Estimates and Their Application to HIV Prevention in the United States: Implications for Cost-Effectiveness Modeling and Future Research Needs.MDM policy & practiceArticle
Corrections and comments
- Commented on by
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveTo compare the HIV transmission risk among patients randomized to episodic versus continuous antiretroviral therapy.
designThis was a substudy of the Strategies of Management of Antiretroviral Therapy study, in which patients were randomized to continuous versus CD4-guided episodic antiretroviral therapy. Participants were surveyed about sexual activity and needle sharing and had laboratory testing for gonorrhea, chlamydia, and syphilis.
resultsA total of 883 patients were enrolled in this study, the mean age of the patients was 45 years, 25% were women, and 78% were on antiretroviral therapy. At baseline, 136 participants (15.4%) had high-risk behavior (vaginal or anal sex without a condom, needle sharing, or incident bacterial sexually transmitted infection). After randomization, the proportion of participants reporting high-risk behavior was stable and did not differ by randomized arm (P = 0.39). Among participants off therapy at baseline, high-risk behavior was less common 4 months after randomization among those who were randomized to start antiretroviral therapy (P = 0.03). HIV transmission risk (high-risk behavior while HIV RNA level >1500 copies/mL) with partners perceived to be HIV uninfected was higher in the episodic therapy arm (P = 0.02).
conclusionsPatients on episodic antiretroviral therapy did not decrease high-risk behavior, and because HIV RNA levels were higher, this strategy may result in increased HIV transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.