ReviewCurrent opinion in allergy and clinical immunology2008
Immune regulatory mechanisms in allergic conjunctivitis: insights from mouse models.
Review in Current opinion in allergy and clinical immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Protocol for spatial profiling of immune cells in the mouse cornea and conjunctiva using NanoString GeoMx DSP and nCounterPro platforms.STAR protocols · 2026Article
- IL-18 receptor axis in allergic conjunctivitis: a multi-omics study.Frontiers in immunology · 2025Article
- Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles.Life (Basel, Switzerland) · 2024Review
- Full thickness 3D in vitro conjunctiva model enables goblet cell differentiation.Scientific reports · 2023Article
- Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation.Advances in experimental medicine and biology · 2022Article
- IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation.Mucosal immunology · 2020Article
- Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease.Journal of leukocyte biology · 2016Article
- T helper subsets in allergic eye disease.Current opinion in allergy and clinical immunology · 2014Review
- Allergic conjunctivitis: a comprehensive review of the literature.Italian journal of pediatrics · 2013Review
- Comparative efficacy of bepotastine besilate 1.5% ophthalmic solution versus olopatadine hydrochloride 0.2% ophthalmic solution evaluated by patient preference.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Levocetirizine inhibits migration of immune cells to lymph nodes and induces treg cells in a murine type I allergic conjunctivitis model.The open ophthalmology journal · 2012Article
- Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways.The Journal of allergy and clinical immunology · 2011Article
- Stress during pregnancy and offspring pediatric disease: A National Cohort Study.Environmental health perspectives · 2011Article
- γδ T cells are required for maximal expression of allergic conjunctivitis.Investigative ophthalmology & visual science · 2011Article
- A mouse model of lamellar intrastromal femtosecond laser keratotomy: ultra-structural, inflammatory, and wound healing responses.Molecular vision · 2011Article
- Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis.Recent patents on inflammation & allergy drug discovery · 2011Review
- Aggravation of conjunctival early-phase reaction by Staphylococcus enterotoxin B via augmentation of IgE production.Japanese journal of ophthalmology · 2010Article
- TSLP and downstream molecules in experimental mouse allergic conjunctivitis.Investigative ophthalmology & visual science · 2010Article
- Conjunctivitis: A Systematic Review.Journal of ophthalmic & vision researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis review highlights recent findings regarding the immune regulation of allergic conjunctivitis. Mouse models have facilitated prospective studies that have not been possible in patients. The availability of gene knockout mice and the wealth of monoclonal antibodies have permitted exquisite dissection of the pathophysiology and immune regulation of allergic conjunctivitis. RECENT
findingsNew insights have emerged in three areas: role of costimulatory molecules in the induction of Th2 immune responses; crucial role of IFN-gamma in the expression of allergic conjunctivitis; and the function of T regulatory cells in shaping conjunctival inflammation once the immune response has been initiated. SUMMARY: Allergic conjunctivitis involves early phase and late phase reactions. The early phase reaction is IgE antibody-dependent, whereas the late phase reaction is IgE-independent and is mediated by inflammatory cells, especially eosinophils. Recent studies on mouse models of allergic conjunctivitis have provided important insights into the immune regulation of both the early phase reaction and late phase reaction of allergic conjunctivitis. Mounting evidence suggests that IFN-gamma is crucial for optimum expression of allergic conjunctivitis. Costimulatory molecules influence the induction of Th2 immune responses and the early phase reaction, whereas regulatory T cells shape the expression of the late phase reaction of allergic conjunctivitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.