ArticleCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology2008
Caveolin and proteasome in tocotrienol mediated myocardial protection.
Article in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Caveolin-3: therapeutic target for diabetic myocardial ischemia/reperfusion injury.Molecular medicine (Cambridge, Mass.) · 2025Review
- The use of vitamin E in ocular health: Bridging omics approaches with Tocopherol and Tocotrienol in the management of glaucoma.Food chemistry. Molecular sciences · 2024Article
- Tocotrienols-enriched Self-nanoemulsifying Drug Delivery System Enhances the Antileukemic Activity of All-trans Retinoic Acid but not Electrocardiogram Alterations Evoked by Its Combination with Arsenic Trioxide.AAPS PharmSciTech · 2023Article
- The importance of caveolin as a target in the prevention and treatment of diabetic cardiomyopathy.Frontiers in immunology · 2022Review
- γ-Tocotrienol Protects against Mitochondrial Dysfunction, Energy Deficits, Morphological Damage, and Decreases in Renal Functions after Renal Ischemia.International journal of molecular sciences · 2021Article
- Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence.Nutrients · 2020Review
- Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities.Nutrition & metabolism · 2018Review
- Comparative hepatoprotective effects of tocotrienol analogs against drug-induced liver injury.Redox biology · 2015Article
- Pharmacological potential of tocotrienols: a review.Nutrition & metabolism · 2014Review
- Article
- Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.Journal of physiology and biochemistry · 2013Article
- Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol.Journal of cellular and molecular medicine · 2012Article
- Caveolin as a potential drug target for cardiovascular protection.Frontiers in physiology · 2012Article
- Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.The Journal of nutritional biochemistry · 2012Article
- Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation.Genes & nutrition · 2012Article
- Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E.Genes & nutrition · 2012Article
- Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.Biochemical pharmacology · 2010Review
- Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection.Journal of cellular and molecular medicine · 2010Article
- The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants.Journal of cellular and molecular medicine · 2010Review
- The ubiquitin-proteasome system in myocardial ischaemia and preconditioning.Cardiovascular research · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.