ArticleJournal of virology2008
Role of hypercytokinemia in NF-kappaB p50-deficient mice after H5N1 influenza A virus infection.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses.Microbiology and immunology · 2026Article
- Inhibition Effects of Patchouli Alcohol, Carvacrol, p-Cymene, Eucalyptol and Their Formulations Against Influenza Virus Pneumonia Through TLR4/NF-κB/NLRP3 Signaling Pathway.Chemical biology & drug design · 2025Article
- Future applications of host direct therapies for infectious disease treatment.Frontiers in immunology · 2024Review
- SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system.Frontiers in cardiovascular medicine · 2024Article
- Spontaneous Myocarditis in Mice Predisposed to Autoimmune Disease: Including Vaccination-Induced Onset.Biomedicines · 2022Article
- Babaodan controls excessive immune responses and may represent a cytokine-targeted agent suitable for COVID-19 treatment.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling.Acta pharmacologica Sinica · 2020Article
- Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses.Respiratory research · 2020Article
- Host-Directed Antiviral Therapy.Clinical microbiology reviews · 2020Review
- Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-κB and MAPKs signalings.BMC complementary medicine and therapies · 2020Article
- Erucic acid fromJournal of pharmaceutical analysis · 2020Article
- Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19).Frontiers in nutrition · 2020Review
- NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients.Frontiers in immunology · 2020Article
- Host Response Comparison of H1N1- and H5N1-Infected Mice Identifies Two Potential Death Mechanisms.International journal of molecular sciences · 2017Article
- 1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice.Inflammation · 2016Article
- H5N1 pathogenesis studies in mammalian models.Virus research · 2013Review
- Infection with influenza A viruses causes changes in promoter DNA methylation of inflammatory genes.Influenza and other respiratory viruses · 2013Article
- miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer.PloS one · 2013Article
- Influenza A viruses target type II pneumocytes in the human lung.The Journal of infectious diseases · 2012Article
- Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages.Medical microbiology and immunology · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During H5N1 influenza virus infection, proinflammatory cytokines are markedly elevated in the lungs of infected hosts. The significance of this dysregulated cytokine response in H5N1-mediated pathogenesis remains to be determined. To investigate the influence of hypercytokinemia, or "cytokine storm," a transgenic mouse technology was used. The classical NF-kappaB pathway regulates the induction of most proinflammatory cytokines. Deletion of the p50 subunit leads to a markedly reduced expression of the NF-kappaB-regulated cytokines and chemokines. Here we show that H5N1 influenza virus infection of this transgenic mouse model resulted in a lack of hypercytokinemia but not in altered pathogenesis.
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