ArticleAmerican journal of physiology. Cell physiology2008
How strict is the correlation between STIM1 and Orai1 expression, puncta formation, and ICRAC activation?
Article in American journal of physiology. Cell physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons.The EMBO journal · 2023Article
- Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling.Cell death & disease · 2020Article
- Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.Science signaling · 2016Article
- RefSOFI for Mapping Nanoscale Organization of Protein-Protein Interactions in Living Cells.Cell reports · 2016Article
- Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease.Nature communications · 2016Article
- Store-Operated Calcium Channels.Physiological reviews · 2015Review
- Symphony of vascular contraction: how smooth muscle cells lose harmony to signal increased vascular resistance in hypertension.Hypertension (Dallas, Tex. : 1979) · 2014Review
- Store-operated Orai channels: structure and function.Current topics in membranes · 2013Review
- Role of molecular determinants of store-operated Ca(2+) entry (Orai1, phospholipase A2 group 6, and STIM1) in focal adhesion formation and cell migration.The Journal of biological chemistry · 2012Article
- Overexpression of Orai1 and STIM1 proteins alters regulation of store-operated Ca2+ entry by endogenous mediators.The Journal of biological chemistry · 2012Article
- Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells.American journal of physiology. Cell physiology · 2012Article
- Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER.Biochimica et biophysica acta · 2011Review
- Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions.Journal of cell science · 2010Article
- Activation and regulation of store-operated calcium entry.Journal of cellular and molecular medicine · 2010Review
- From the Cover: STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain.AIMS biophysicsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Stromal interaction molecule 1 (STIM1) and Orai1 have been identified as crucial elements of the store-operated Ca(2+) entry (SOCE) pathway, but the mechanism of their functional interaction remains controversial. It is now well established that, upon depletion of the stores, both molecules can accumulate and colocalize in specific areas (puncta) where the endoplasmic reticulum comes in close proximity to the plasma membrane. Some models propose a direct interaction between STIM1 and Orai1 as the most straightforward mechanism for signal transduction from the stores to the plasma membrane. To test some of the predictions of a conformational coupling model, we assessed how tight the relationships are between STIM1 and Orai1 expression, puncta formation, and SOCE activation. Here we present evidence that STIM1 accumulates in puncta equally well in the presence or absence of Orai1 expression, that STIM1 accumulation is not sufficient for Orai1 accumulation in the same areas, and that normal Ca(2+) release-activated Ca(2+) current (I(CRAC)) can be activated in STIM1-deficient cells. These data challenge the idea of direct conformational coupling between STIM1 and Orai1 as a viable mechanism of puncta formation and SOCE activation and uncover greater complexity in their relationship, which may require additional intermediate elements.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.