ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Maternal microchimerism and cell-mediated immune-modulation enhance engraftment following semi-allogenic intrauterine transplantation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives.Frontiers in immunology · 2021Review
- B cells as antigen-presenting cells in transplantation rejection and tolerance.Cellular immunology · 2020Review
- Immune monitoring of transplant patients in transient mixed chimerism tolerance trials.Human immunology · 2018Review
- Mechanisms of Mixed Chimerism-Based Transplant Tolerance.Trends in immunology · 2017Review
- APC-targeted proinsulin expression inactivates insulin-specific memory CD8Immunology and cell biology · 2017Article
- Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance.Stem cell research & therapy · 2017Article
- Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
- Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance.Current opinion in organ transplantation · 2015Review
- B cells with immune-regulating function in transplantation.Nature reviews. Nephrology · 2014Review
- IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells.European journal of immunology · 2012Article
- Experimental models of B cell tolerance in transplantation.Seminars in immunology · 2012Review
- Translating tolerogenic therapies to the clinic - where do we stand?Frontiers in immunology · 2012Article
- Article
- Hematopoietic chimerism and transplantation tolerance: a role for regulatory T cells.Frontiers in immunology · 2011Article
- Transplantation tolerance through mixed chimerism.Nature reviews. Nephrology · 2010Review
- The power and the promise of restimulation-induced cell death in human immune diseases.Immunological reviews · 2010Review
- CD47 is required for suppression of allograft rejection by donor-specific transfusion.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Mechanisms of transplantation tolerance in animals and humans.Transplantation · 2009Article
- Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials.Transplantation · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Mixed chimerism and donor-specific tolerance are achieved in mice receiving 3 Gy of total body irradiation and anti-CD154 mAb followed by allogeneic bone marrow (BM) transplantation. In this model, recipient CD4 cells are critically important for CD8 tolerance. To evaluate the role of CD4 cells recognizing donor MHC class II directly, we used class II-deficient donor marrow and were not able to achieve chimerism unless recipient CD8 cells were depleted, indicating that directly alloreactive CD4 cells were necessary for CD8 tolerance. To identify the MHC class II(+) donor cells promoting this tolerance, we used donor BM lacking certain cell populations or used positively selected cell populations. Neither donor CD11c(+) dendritic cells, B cells, T cells, nor donor-derived IL-10 were critical for chimerism induction. Purified donor B cells induced early chimerism and donor-specific cell-mediated lympholysis tolerance in both strain combinations tested. In contrast, positively selected CD11b(+) monocytes/myeloid cells did not induce early chimerism in either strain combination. Donor cell preparations containing B cells were able to induce early deletion of donor-reactive TCR-transgenic 2C CD8 T cells, whereas those devoid of B cells had reduced activity. Thus, induction of stable mixed chimerism depends on the expression of MHC class II on the donor marrow, but no requisite donor cell lineage was identified. Donor BM-derived B cells induced early chimerism, donor-specific cell-mediated lympholysis tolerance, and deletion of donor-reactive CD8 T cells, whereas CD11b(+) cells did not. Thus, BM-derived B cells are potent tolerogenic APCs for alloreactive CD8 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.