ArticleJournal of immunology (Baltimore, Md. : 1950)2008
IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo.Allergy · 2012Trial
- The antioxidant barrier, oxidative/nitrosative stress, and protein glycation in allergy: from basic research to clinical practice.Frontiers in immunology · 2024Review
- Review
- Review
- IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils.Cell death & disease · 2018Article
- Inhibition of airway inflammation in a cockroach allergen model of asthma by agonists of miRNA-33b.Scientific reports · 2017Article
- Peroxisome proliferator-activated receptor γ agonist suppresses mast cell maturation and induces apoptosis.Molecular medicine reports · 2017Article
- Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.PloS one · 2016Article
- Fluorogen-activating proteins provide tunable labeling densities for tracking FcεRI independent of IgE.ACS chemical biology · 2015Article
- Article
- DJ-1 regulates mast cell activation and IgE-mediated allergic responses.The Journal of allergy and clinical immunology · 2013Article
- Antibodies and IL-3 support helminth-induced basophil expansion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases.Endocrine reviews · 2012Review
- Cytokinergic IgE Action in Mast Cell Activation.Frontiers in immunology · 2012Article
- Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.The Journal of biological chemistry · 2011Article
- Uptake and distribution of fullerenes in human mast cells.Nanomedicine : nanotechnology, biology, and medicine · 2010Article
- Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2009Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
We show in this study that the ability of five different monomeric IgEs to enhance murine bone marrow-derived mast cell (BMMC) survival correlates with their ability to stimulate extracellular calcium (Ca(2+)) entry. However, whereas IgE+Ag more potently stimulates Ca(2+) entry, it does not enhance survival under our conditions. Exploring this further, we found that whereas all five monomeric IgEs stimulate a less robust Ca(2+) entry than IgE+Ag initially, they all trigger a more prolonged Ca(2+) influx, generation of reactive oxygen species (ROS), and ERK phosphorylation. These prolonged signaling events correlate with their survival-enhancing ability and positively feedback on each other to generate the prosurvival cytokine, IL-3. Interestingly, the prolonged ERK phosphorylation induced by IgE appears to be regulated by a MAPK phosphatase rather than MEK. IgE-induced ROS generation, unlike that triggered by IgE+Ag, is not mediated by 5-lipoxygenase. Moreover, ROS inhibitors, which block both IgE-induced ROS production and Ca(2+) influx, convert the prolonged ERK phosphorylation induced by IgE into the abbreviated phosphorylation pattern observed with IgE+Ag and prevent IL-3 generation. In support of the essential role that IgE-induced ROS plays in IgE-enhanced BMMC survival, we found the addition of H(2)O(2) to IgE+Ag-stimulated BMMCs leads to IL-3 secretion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.