ArticleProceedings of the National Academy of Sciences of the United States of America2008
Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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Who cites it
95 citing papers in PubMed, 166 citations in OpenAlex.
- Human enterovirus infections in children at increased risk for type 1 diabetes: the Babydiet study.Diabetologia · 2011Trial
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- Evidence of multiple bacterial, viral, and parasitic infectious disease agents inInfection ecology & epidemiology · 2025Article
- Biographical Feature: Charles Y. Chiu, M.D., Ph.D.Journal of clinical microbiology · 2024Article
- Critical role of TLR activation in viral replication, persistence, and pathogenicity of Theiler's virus.Frontiers in immunology · 2023Review
- Embracing the heterogeneity of natural viruses in mouse studies.The Journal of general virology · 2022Article
- Excessive Innate Immunity Steers Pathogenic Adaptive Immunity in the Development of Theiler's Virus-Induced Demyelinating Disease.International journal of molecular sciences · 2021Review
- HEPN RNases - an emerging class of functionally distinct RNA processing and degradation enzymes.Critical reviews in biochemistry and molecular biology · 2021Review
- First Occurrence of Saffold Virus in Sewage and River Water Samples in Karaj, Iran.Food and environmental virology · 2020Article
- Illumina sequencing of clinical samples for virus detection in a public health laboratory.Scientific reports · 2019Article
- Infection and Propagation of Astrovirus VA1 in Cell Culture.Current protocols in microbiology · 2019Article
- Article
- Frequent detection of Saffold cardiovirus in adenoids.PloS one · 2019Article
- Laboratory Methods in Molecular Epidemiology: Viral Infections.Microbiology spectrum · 2018Review
- Article
- Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation.Acta neurologica Scandinavica · 2017Review
- Evolution of selective-sequencing approaches for virus discovery and virome analysis.Virus research · 2017Review
- Saffold virus, an emerging human cardiovirus.Reviews in medical virology · 2017Review
- Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice.Virology journal · 2016Article
- Intracerebral Inoculation of Mouse-Passaged Saffold Virus Type 3 Affects Cerebellar Development in Neonatal Mice.Journal of virology · 2016Article
35 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Cardioviruses comprise a genus of picornaviruses that cause severe illnesses in rodents, but little is known about the prevalence, diversity, or spectrum of disease of such agents among humans. A single cardiovirus isolate, Saffold virus, was cultured in 1981 in stool from an infant with fever. Here, we describe the identification of a group of human cardioviruses that have been cloned directly from patient specimens, the first of which was detected using a pan-viral microarray in respiratory secretions from a child with influenza-like illness. Phylogenetic analysis of the nearly complete viral genome (7961 bp) revealed that this virus belongs to the Theiler's murine encephalomyelitis virus (TMEV) subgroup of cardioviruses and is most closely related to Saffold virus. Subsequent screening by RT-PCR of 719 additional respiratory specimens [637 (89%) from patients with acute respiratory illness] and 400 cerebrospinal fluid specimens from patients with neurological disease (aseptic meningitis, encephalitis, and multiple sclerosis) revealed no evidence of cardiovirus infection. However, screening of 751 stool specimens from 498 individuals in a gastroenteritis cohort resulted in the detection of 6 additional cardioviruses (1.2%). Although all 8 human cardioviruses (including Saffold virus) clustered together by phylogenetic analysis, significant sequence diversity was observed in the VP1 gene (66.9%-100% pairwise amino acid identities). These findings suggest that there exists a diverse group of novel human Theiler's murine encephalomyelitis virus-like cardioviruses that hitherto have gone largely undetected, are found primarily in the gastrointestinal tract, can be shed asymptomatically, and have potential links to enteric and extraintestinal disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.