ReviewSeminars in immunology2008
Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.
Review in Seminars in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Immune Organoids: A Review of Their Applications in Cancer and Autoimmune Disease Immunotherapy.Current issues in molecular biology · 2025Review
- A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.Genes & development · 2025Article
- TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice.Cellular & molecular immunology · 2024Article
- Matrix stability and bifurcation analysis by a network-based approach.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Generating hematopoietic cells from human pluripotent stem cells: approaches, progress and challenges.Cell regeneration (London, England) · 2023Review
- GATA2-Mediated Transcriptional Activation of Notch3 Promotes Pancreatic Cancer Liver Metastasis.Molecules and cells · 2022Article
- Article
- The Notch signaling pathway involvement in innate lymphoid cell biology.Biomedical journal · 2021Review
- RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors.Nature immunology · 2019Article
- Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells.Cell stem cell · 2019Article
- BACH transcription factors in innate and adaptive immunity.Nature reviews. Immunology · 2017Review
- Bcl11b-A Critical Neurodevelopmental Transcription Factor-Roles in Health and Disease.Frontiers in cellular neuroscience · 2017Review
- Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells.Nature communications · 2016Article
- Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.Oncotarget · 2015Article
- Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells.The Journal of biological chemistry · 2015Article
- Myocyte enhancer factor 2C in hematopoiesis and leukemia.Oncogene · 2014Review
- Systematic identification of transcriptional regulatory modules from protein-protein interaction networks.Nucleic acids research · 2014Article
- Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transcriptional regulation of IL-15 expression during hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
T-cell precursors remain developmentally plastic for multiple cell generations after entering the thymus, preserving access to developmental alternatives of macrophage, dendritic-cell, and even mast-cell fates. The underlying regulatory basis of this plasticity is that early T-cell differentiation depends on transcription factors which can also promote alternative developmental programs. Interfactor competition, together with environmental signals, keep these diversions under control. Here the pathways leading to several lineage alternatives for early pro-T-cells are reviewed, with close focus on the mechanisms of action of three vital factors, GATA-3, PU.1, and Notch-Delta signals, whose counterbalance appears to be essential for T-cell specification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.