ArticlePLoS biology2008
Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Organelle-specific fluorescent probes for live imaging at the nanoscale.Science China. Life sciences · 2026Review
- Two Kinesin-14A Motors Oligomerize to Drive Poleward Microtubule Convergence for Acentrosomal Spindle Morphogenesis inFrontiers in cell and developmental biology · 2022Article
- Inhibition of polar actin assembly by astral microtubules is required for cytokinesis.Nature communications · 2021Article
- Polar relaxation by dynein-mediated removal of cortical myosin II.The Journal of cell biology · 2020Article
- Molecular mechanisms of contractile-ring constriction and membrane trafficking in cytokinesis.Biophysical reviews · 2018Review
- A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis ineLife · 2018Article
- TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.The Journal of cell biology · 2018Article
- Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator.Nature communications · 2017Article
- LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring.Molecular biology of the cell · 2017Article
- An equatorial contractile mechanism drives cell elongation but not cell division.PLoS biology · 2014Article
- The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis.The Journal of cell biology · 2013Article
- A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis.Developmental cell · 2013Article
- Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast.The Journal of cell biology · 2012Article
- Centralspindlin and chromosomal passenger complex behavior during normal and Rappaport furrow specification in echinoderm embryos.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis.The Journal of cell biology · 2011Article
- Role of Survivin in cytokinesis revealed by a separation-of-function allele.Molecular biology of the cell · 2011Article
- The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.The Journal of cell biology · 2011Article
- Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2011Review
- Article
- Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the zebrafish.Molecular reproduction and development · 2010Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinesis is powered by the contraction of actomyosin filaments within the newly assembled contractile ring. Microtubules are a spindle component that is essential for the induction of cytokinesis. This induction could use central spindle and/or astral microtubules to stimulate cortical contraction around the spindle equator (equatorial stimulation). Alternatively, or in addition, induction could rely on astral microtubules to relax the polar cortex (polar relaxation). To investigate the relationship between microtubules, cortical stiffness, and contractile ring assembly, we used different configurations of microtubules to manipulate the distribution of actin in living silkworm spermatocytes. Mechanically repositioned, noninterdigitating microtubules can induce redistribution of actin at any region of the cortex by locally excluding cortical actin filaments. This cortical flow of actin promotes regional relaxation while increasing tension elsewhere (normally at the equatorial cortex). In contrast, repositioned interdigitating microtubule bundles use a novel mechanism to induce local stimulation of contractility anywhere within the cortex; at the antiparallel plus ends of central spindle microtubules, actin aggregates are rapidly assembled de novo and transported laterally to the equatorial cortex. Relaxation depends on microtubule dynamics but not on RhoA activity, whereas stimulation depends on RhoA activity but is largely independent of microtubule dynamics. We conclude that polar relaxation and equatorial stimulation mechanisms redundantly supply actin for contractile ring assembly, thus increasing the fidelity of cleavage.
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