ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2008
Mechanisms of ileal adaptation for glucose absorption after proximal-based small bowel resection.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Molecular Mechanisms of Intestinal Adaptation in Short Bowel Syndrome: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Colonic Adaptation Postileal Resection: Bile Acid Absorption in an Ileal Resection Mouse Model.Gastroenterology research and practice · 2025Article
- Evidence of glucose absorption in a neoformed intestine.Updates in surgery · 2022Article
- Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?Seminars in immunopathology · 2019Review
- Single-Cell Analysis Reveals Regional Reprogramming During Adaptation to Massive Small Bowel Resection in Mice.Cellular and molecular gastroenterology and hepatology · 2019Article
- Mechanisms of weight loss and improved metabolism following bariatric surgery.Annals of the New York Academy of Sciences · 2018Review
- Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection.Biology open · 2017Article
- Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution?Annals of the New York Academy of Sciences · 2017Review
- Extensive Intestinal Resection Triggers Behavioral Adaptation, Intestinal Remodeling and Microbiota Transition in Short Bowel Syndrome.Microorganisms · 2016Review
- Long-term Effect of Ileal Transposition on Adipokine Serum Level in Zucker (Orl)-Lepr(fa) Fatty Rats.Obesity surgery · 2015Article
- The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes.Cell metabolism · 2015Review
- Intestinal mucosal atrophy and adaptation.World journal of gastroenterology · 2012Review
- Effects and mechanism of duodenal-jejunal bypass and sleeve gastrectomy on GLUT2 and glucokinase in diabetic Goto-Kakizaki rats.European journal of medical research · 2012Article
- Short bowel syndrome in children: current and potential therapies.Paediatric drugs · 2012Review
- Peptide absorption after massive proximal small bowel resection: mechanisms of ileal adaptation.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- Differentiating passive from transporter-mediated uptake by PepT1: a comparison and evaluation of four methods.The Journal of surgical research · 2011Article
- Intestinal adaptation for oligopeptide absorption via PepT1 after massive (70%) mid-small bowel resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- Role of vagal innervation in diurnal rhythm of intestinal peptide transporter 1 (PEPT1).Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThe hexose transmembrane transporters SGLT1 and GLUT2 are present in low quantities in ileum where little glucose absorption occurs normally; however, glucose uptake in ileum is highly adaptable after small bowel resection. HYPOTHESIS: Ileal adaptability for glucose absorption after jejunal resection is mediated predominately by upregulation of GLUT2.
methodsRats underwent 70% proximal-based jejunoileal resection. Transporter-mediated glucose uptake was measured in proximal and distal remnant ileum 1 and 4 wk postoperatively (n = 6 rats, each) and in corresponding ileal segments in control and 1 wk sham laparotomy rats (n = 6, each) without and with selective inhibitors of SGLT1 and GLUT2. In separate groups of rats (n = 6, each), protein (Western blots), mRNA (reverse transcriptase polymerase chain reaction [RT-PCR]), and villus height (histomorphology) were measured.
resultsAfter 70% proximal intestinal resection, there was no dramatic change in protein or mRNA expression per cell of either SGLT1 or GLUT2, but median glucose uptake (nmol/cm/min) increased markedly from 52 (range 28-63) in controls to 118 (range 80-171) at 1 wk, and 203 (range 93-248) at 4 wk (p < or = 0.04 each) correlating with change in villus height (p < or = 0.03).
conclusionsIleal adaptation for glucose transport occurs through cellular proliferation (hyperplasia) and not through cellular upregulation of glucose transporters.
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