ArticleCritical care medicine2008
Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury.
Article in Critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Improving Care of Acute Lung Injury Patients (ICAP) Study
Nutrition and Exercise in Critical Illness (The NEXIS Trial): A Randomized Trial of Combined Cycle Ergometry and Amino Acids in the ICU
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Depression in general intensive care unit survivors: a systematic review.Intensive care medicine · 2009Pooled it
- The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury.American journal of respiratory and critical care medicine · 2012Trial
- Supporting Post-ICU Recovery: A Narrative Review for General Practitioners.Diseases (Basel, Switzerland) · 2025Review
- Quality of Life and Mental Health in COVID-ARDS Survivors After V-V ECMO Support: Results from the Freiburg ECMO Outcome Study (FEOS).Journal of clinical medicine · 2025Article
- Post-Intensive Care Syndrome as a Burden for Patients and Their Caregivers: A Narrative Review.Journal of clinical medicine · 2024Review
- Timely Albumin Infusion May Improve Resource Utilization in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis.BioMed research international · 2024Article
- Unveiling the Hidden Burden: Mapping the Landscape of Post-Intensive Care Syndrome Research. A Bibliometric Study and Visualization Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Timely Albumin Improves Survival in Patients With Cirrhosis on Diuretic Therapy Who Develop Acute Kidney Injury: Real-World Evidence in the United States.Gastro hep advances · 2023Article
- Post-Intensive Care Syndrome in Survivors from Critical Illness including COVID-19 Patients: A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Participant Retention in Follow-Up Studies of Acute Respiratory Failure Survivors.Respiratory care · 2020Article
- The quality of acute intensive care and the incidence of critical events have an impact on health-related quality of life in survivors of the acute respiratory distress syndrome - a nationwide prospective multicenter observational study.German medical science : GMS e-journal · 2020Observational
- Review: Post-Intensive Care Syndrome: Unique Challenges in the Neurointensive Care Unit.Neurocritical care · 2019Review
- Acute respiratory distress syndrome.Nature reviews. Disease primers · 2019Review
- Post-intensive care unit syndrome in gynecologic oncology patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers.Intensive care medicine · 2016Review
- Cooccurrence of and remission from general anxiety, depression, and posttraumatic stress disorder symptoms after acute lung injury: a 2-year longitudinal study.Critical care medicine · 2015Article
- Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study.Psychological medicine · 2013Article
- General anxiety symptoms after acute lung injury: predictors and correlates.Journal of psychosomatic research · 2013Article
- Symptoms of depression in survivors of severe sepsis: a prospective cohort study of older Americans.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2013Article
- Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study.Critical care (London, England) · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveTo evaluate the association between intensive care unit blood glucose levels and depression after acute lung injury.
designProspective cohort study.
settingTwelve intensive care units in four hospitals in Baltimore, MD. PATIENTS: Consecutive acute lung injury survivors (n = 104) monitored during 1717 intensive care unit patient-days and screened for depression at 3 months after acute lung injury.
interventionsNone. MEASUREMENTS AND MAIN
resultsThe prevalence of a positive screening test for depression (Hospital Anxiety and Depression subscale score > or = 8) at follow-up was 28%. After adjustment for confounders, patients with a mean daily minimum intensive care unit glucose level < 100 mg/dL had significant increases in mean depression score (2.1 points, 95% confidence interval 0.6-3.7) and in the likelihood of a positive depression screening test (relative risk 2.6, 95% confidence interval 1.2-4.2). Patients with documented hypoglycemia < 60 mg/dL during their intensive care unit stay also had greater symptoms of depression (2.0 points, 95% confidence interval 0.5-3.5; relative risk 3.6, 95% confidence interval 1.8-5.1). Other factors independently associated with a positive depression screening test included body mass index > 40 kg/m2 (relative risk 3.3, 95% confidence interval 1.2-4.2), baseline depression/anxiety (relative risk 3.9, 95% confidence interval 1.5-6.5), and mean daily intensive care unit benzodiazepine dose > 100 mg of midazolam-equivalent agent (relative risk 2.4, 95% confidence interval 1.1-3.8).
conclusionsHypoglycemia in the intensive care unit is associated with an increased risk of positive screening for depression during early recovery from acute lung injury. Baseline depressive symptoms, morbid obesity, and intensive care unit benzodiazepine dose were also associated with postacute lung injury depressive symptoms. These findings warrant increased glucose monitoring for intensive care unit patients at risk for hypoglycemia and further research on how patient and intensive care unit management factors may contribute to postintensive care unit depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.