ArticleInfection and immunity2008
Responses of cattle to gastrointestinal colonization by Escherichia coli O157:H7.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Vaccination with type III secreted proteins leads to decreased shedding in calves after experimental infection with Escherichia coli O157.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2011Trial
- Isolation and Characterization of NovelBiomedicines · 2024Article
- Differential Colonization and Mucus Ultrastructure Visualization in Bovine Ileal and Rectal Organoid-Derived Monolayers Exposed to EnterohemorrhagicInternational journal of molecular sciences · 2024Article
- Accessible luminal interface of bovine rectal organoids generated from cryopreserved biopsy tissues.PloS one · 2024Article
- Untangling the role of environmental and host-related determinants for on-farm transmission of verotoxin-producingInfection ecology & epidemiology · 2024Article
- CommensalAnimals : an open access journal from MDPI · 2023Article
- EntericFrontiers in veterinary science · 2022Review
- Mucosal IFNγ production and potential role in protection in Escherichia coli O157:H7 vaccinated and challenged cattle.Scientific reports · 2021Article
- MicroRNAomes of Cattle Intestinal Tissues Revealed Possible miRNA Regulated Mechanisms Involved inFrontiers in cellular and infection microbiology · 2021Article
- Early immune innate hallmarks and microbiome changes across the gut during Escherichia coli O157: H7 infection in cattle.Scientific reports · 2020Article
- The Role ofToxins · 2020Review
- Changes in bacterial community composition of Escherichia coli O157:H7 super-shedder cattle occur in the lower intestine.PloS one · 2017Article
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- Longitudinal Study of Two Irish Dairy Herds: Low Numbers of Shiga Toxin-ProducingFrontiers in microbiology · 2016Article
- 'Super' or just 'above average'? Supershedders and the transmission of Escherichia coli O157:H7 among feedlot cattle.Journal of the Royal Society, Interface · 2015Article
- Strain-dependent cellular immune responses in cattle following Escherichia coli O157:H7 colonization.Infection and immunity · 2014Article
- The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment.Cellular microbiology · 2014Article
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- Article
- Carbohydrate utilization by enterohaemorrhagic Escherichia coli O157:H7 in bovine intestinal content.Environmental microbiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent research has established that the terminal rectum is the predominant colonization site of enterohemorrhagic Escherichia coli O157:H7 in cattle. The main aim of the present work was to investigate pathological changes and associated immune responses at this site in animals colonized with E. coli O157:H7. Tissue and gastrointestinal samples from a total of 22 weaned Holstein-cross calves challenged with E. coli O157:H7 were analyzed for bacterial colonization and pathology. Five unexposed age-matched calves were used as comparative negative controls. E. coli O157:H7 bacteria induced histopathological alterations of the rectal mucosa with enterocyte remodeling. This was often associated with removal of the colonized epithelial layer. Immunogold labeling and transmission electron microscopy (TEM) showed E. coli O157 bacteria on pedestals, as part of attaching and effacing lesions. These pathological changes induced a local infiltration of neutrophils that was quantified as larger in infected animals. Rectal mucosal immunoglobulin A responses were detected against the E. coli O157:H7 antigen. This work presents evidence that E. coli O157:H7 is not a commensal bacteria in the bovine host and that the mucosal damage produced by E. coli O157:H7 colonization of the terminal rectum induces a quantifiable innate immune response and production of specific mucosal antibodies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.