ArticleInfection and immunity2008
Functional analysis of the Salmonella pathogenicity island 2-mediated inhibition of antigen presentation in dendritic cells.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- The interplay betweenCell insight · 2025Review
- A pan-genome perspective on the evolutionary dynamics of polyphyly, virulence, and antibiotic resistance inCurrent research in food science · 2025Article
- Infection biology ofEcoSal Plus · 2024Review
- Functional Divergence of the ParalogInternational journal of molecular sciences · 2024Review
- Specificities and redundancies in the NEL family of bacterial E3 ubiquitin ligases ofFrontiers in immunology · 2024Article
- Strategies adopted by Salmonella to survive in host: a review.Archives of microbiology · 2023Review
- Speaking the host language: howMicrobiology (Reading, England) · 2023Review
- The Attenuation Mechanism and Live Vaccine Potential of a Low-VirulenceJournal of microbiology and biotechnology · 2023Article
- The NEL Family of Bacterial E3 Ubiquitin Ligases.International journal of molecular sciences · 2022Review
- Revisiting PersistentPathogens (Basel, Switzerland) · 2021Review
- New Insights on the Early Interaction Between Typhoid and Non-typhoidFrontiers in microbiology · 2021Review
- Review
- BioID screen of Salmonella type 3 secreted effectors reveals host factors involved in vacuole positioning and stability during infection.Nature microbiology · 2019Article
- Virulence Factors in Salmonella Typhimurium: The Sagacity of a Bacterium.Current microbiology · 2019Review
- Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins.PLoS pathogens · 2018Article
- The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation.Cell host & microbe · 2016Article
- Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis.Virulence · 2016Article
- Role of host cell-derived amino acids in nutrition of intracellular Salmonella enterica.Infection and immunity · 2015Article
- Salmonellae interactions with host processes.Nature reviews. Microbiology · 2015Review
- Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development.European journal of immunology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica is a facultative intracellular pathogen that is able to modify host cell functions by means of effector proteins translocated by the type III secretion system (T3SS) encoded by Salmonella Pathogenicity Island 2 (SPI2). The SPI2-T3SS is also active in Salmonella after uptake by murine bone marrow-derived dendritic cells (BM-DC). We have previously shown that intracellular Salmonella interfere with the ability of BM-DC to stimulate antigen-dependent T-cell proliferation in an SPI2-T3SS-dependent manner. We observed that Salmonella-mediated inhibition of antigen presentation could be restored by external addition of peptides on major histocompatibility complex class II (MHC-II). The processing of antigens in Salmonella-infected cells was not altered; however, the intracellular loading of peptides on MHC-II was reduced as a function of the SPI2-T3SS. We set out to identify the effector proteins of the SPI2-T3SS involved in inhibition of antigen presentation and demonstrated that effector proteins SifA, SspH2, SlrP, PipB2, and SopD2 were equally important for the interference with antigen presentation, whereas SseF and SseG contributed to a lesser extent to this phenotype. These observations indicate the presence of a host cell-specific virulence function of a novel subset of SPI2-effector proteins.
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