Evidence map›Paper›PMID 18765693›Full record

ArticleAntimicrobial agents and chemotherapy2008

Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of Streptococcus pyogenes.

Christoph B Duesberg, Surbhi Malhotra-Kumar, Herman Goossens, Lesley McGee, Keith P Klugman, Tobias Welte, Mathias W R Pletz

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Characterization of levofloxacin non-susceptible clinical Streptococcus pyogenes isolated in the central part of Italy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014
    Article
  7. Article
  8. Review
  9. Article
  10. Molecular markers for discriminating Streptococcus pyogenes and S. dysgalactiae subspecies equisimilis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Christoph B DuesbergDepartment of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Surbhi Malhotra-Kumar
Herman Goossens
Lesley McGee
Keith P Klugman
Tobias Welte
Mathias W R Pletz
University of Antwerp · BEEmory University · USMedizinische Hochschule Hannover · DEOffice of Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluoroquinolone resistance in Streptococcus pyogenes has been reported only anecdotally, but a recent Belgian surveillance study found a rate of nonsusceptibility of 5.4%. From an analysis of these isolates, we show that interspecies horizontal gene transfer within the parC quinolone resistance-determining region is a frequent phenomenon that might contribute to fluoroquinolone resistance.

Indexed as

Anti-Bacterial AgentsDNA Topoisomerase IVDrug Resistance, BacterialFluoroquinolonesGenes, BacterialGene Transfer, HorizontalHumansPhylogenyRecombination, GeneticSpecies SpecificityStreptococcal InfectionsStreptococcus pyogenesAnti-Bacterial AgentsDNA Topoisomerase IVFluoroquinolones

Identifiers

PMID18765693
PMCPMC2573148
OpenAlexW2169462245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.