ArticleThe Journal of biological chemistry2008
Novel variants of Oct-3/4 gene expressed in mouse somatic cells.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Multifaceted role ofiScience · 2026Article
- Ectopic expression of OCT4B1 Decreases Fertility Rate and Changes Sperm Parameters in Transgenic Mice.Iranian journal of biotechnology · 2022Article
- Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma.BMC cancer · 2020Article
- The Role of Microenvironment in Preserving the Potency of Adult Porcine Pulmonary Valve Stem CellsInternational journal of stem cells · 2018Article
- Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.Cellular and molecular life sciences : CMLS · 2018Review
- Investigation of the cellular reprogramming phenomenon referred to as stimulus-triggered acquisition of pluripotency (STAP).Scientific reports · 2016Article
- Evidence that the population of quiescent bone marrow-residing very small embryonic/epiblast-like stem cells (VSELs) expands in response to neurotoxic treatment.Journal of cellular and molecular medicine · 2014Article
- Role of Oct4 in the early embryo development.Cell regeneration (London, England) · 2014Review
- Constitutive expression of the embryonic stem cell marker OCT4 in bovine somatic donor cells influences blastocysts rate and quality after nucleus transfer.In vitro cellular & developmental biology. Animal · 2013Article
- Murine bone marrow Lin⁻Sca⁻1⁺CD45⁻ very small embryonic-like (VSEL) cells are heterogeneous population lacking Oct-4A expression.PloS one · 2013Article
- Autochthonous mouse melanoma and mammary tumors do not express the pluripotency genes Oct4 and Nanog.PloS one · 2013Article
- The novel function of Oct3/4 in mouse tooth development.Histochemistry and cell biology · 2012Article
- Alternative splicing in self-renewal of embryonic stem cells.Stem cells international · 2011Article
- Dynamic methylation and expression of Oct4 in early neural stem cells.Journal of anatomy · 2010Article
- Concise review: isoforms of OCT4 contribute to the confusing diversity in stem cell biology.Stem cells (Dayton, Ohio) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that Oct-3/4 may regulate self-renewal in somatic stem cells, as it does in embryonic stem cells. However, recent reports raise the possibility that detection of human Oct-3/4 expression by RT-PCR is prone to artifacts generated by pseudogene transcripts and argue against a role for Oct-3/4 in somatic cells. In this study, we clarified Oct-3/4 expression in mouse somatic tissues using designed PCR primers, which can exclude amplification of its pseudogenes. We found that novel alternative transcripts are indeed expressed in somatic tissues, rather than the normal length transcripts in germline and ES cells. The alternative transcripts indicate the expression of two kinds of truncated proteins. Furthermore, we determined novel promoter regions that are sufficient for the expression of Oct-3/4 transcript variants in somatic cells. These findings provide new insights into the postnatal role of Oct-3/4 in somatic tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.