ArticleMolecular and cellular biology2008
The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Role of COUP‑TFII in cardiovascular diseases and colorectal cancer: Insights into the molecular mechanisms and clinical relevance (Review).Molecular medicine reports · 2025Review
- Article
- NR2F2 plays a major role in insulin-induced epithelial-mesenchymal transition in breast cancer cells.BMC cancer · 2020Article
- COUP-TFII in Health and Disease.Cells · 2019Review
- COUP-TFII revisited: Its role in metabolic gene regulation.Steroids · 2019Review
- Seven-Up Is a Novel Regulator of Insulin Signaling.Genetics · 2018Article
- The role of the glucose-sensing transcription factor carbohydrate-responsive element-binding protein pathway in termite queen fertility.Open biology · 2016Article
- Transcriptional Factors Mediating Retinoic Acid Signals in the Control of Energy Metabolism.International journal of molecular sciences · 2015Review
- Rare variants in NR2F2 cause congenital heart defects in humans.American journal of human genetics · 2014Article
- The expression of Apoc3 mRNA is regulated by HNF4α and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells.Molecular and cellular biochemistry · 2014Article
- Hypothalamic ventromedial COUP-TFII protects against hypoglycemia-associated autonomic failure.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Multiple roles of COUP-TFII in cancer initiation and progression.Journal of molecular endocrinology · 2012Review
- COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways.PloS one · 2012Article
- Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity.PloS one · 2012Article
- CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability.EMBO reports · 2011Article
- Coup d'Etat: an orphan takes control.Endocrine reviews · 2011Review
- The nutritional induction of COUP-TFII gene expression in ventromedial hypothalamic neurons is mediated by the melanocortin pathway.PloS one · 2010Article
- SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII.Blood · 2009Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COUP-TFII has an important role in regulating metabolism in vivo. We showed this previously by deleting COUP-TFII from pancreatic beta cells in heterozygous mutant mice, which led to abnormal insulin secretion. Here, we report that COUP-TFII expression is reduced in the pancreas and liver of mice refed with a carbohydrate-rich diet and in the pancreas and liver of hyperinsulinemic and hyperglycemic mice. In pancreatic beta cells, COUP-TFII gene expression is repressed by secreted insulin in response to glucose through Foxo1 signaling. Ex vivo COUP-TFII reduces insulin production and secretion. Our results suggest that beta cell insulin secretion is under the control of an autocrine positive feedback loop by alleviating COUP-TFII repression. In hepatocytes, both insulin, through Foxo1, and high glucose concentrations repress COUP-TFII expression. We demonstrate that this negative glucose effect involves ChREBP expression. We propose that COUP-TFII acts in a coordinate fashion to control insulin secretion and glucose metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.