ArticleJournal of cell science2008
Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload.
Article in Journal of cell science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- TRPs-NCX2 Axis Jointly Preserves Pancreatic Beta Cell Susceptibility/Sensitivity to Elevated Glucose.Cells · 2026Article
- The cGAS-STING pathway: a therapeutic target in diabetes and its complications.Burns & trauma · 2024Review
- The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023Review
- Plasma Membrane CaFunction (Oxford, England) · 2022Article
- Regulation of Store-Operated CaCells · 2021Review
- STIM1 activation of Orai1.Cell calcium · 2019Review
- CaNature communications · 2017Article
- Article
- Diseases caused by mutations in ORAI1 and STIM1.Annals of the New York Academy of Sciences · 2015Review
- Store-Operated Calcium Channels.Physiological reviews · 2015Review
- Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Generation of Red-Shifted Cameleons for Imaging Ca²⁺ Dynamics of the Endoplasmic Reticulum.Sensors (Basel, Switzerland) · 2015Article
- IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake.Journal of cell science · 2014Article
- Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA.Nature communications · 2014Article
- Oligomerization and Ca2+/calmodulin control binding of the ER Ca2+-sensors STIM1 and STIM2 to plasma membrane lipids.Bioscience reports · 2013Article
- Molecular regulation of CRAC channels and their role in lymphocyte function.Cellular and molecular life sciences : CMLS · 2013Review
- The endocannabinoid N-arachidonoyl glycine (NAGly) inhibits store-operated Ca2+ entry by preventing STIM1-Orai1 interaction.Journal of cell science · 2013Article
- Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.PloS one · 2013Article
- Orai-STIM-mediated Ca2+ release from secretory granules revealed by a targeted Ca2+ and pH probe.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Cellular and molecular life sciences : CMLS · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The stromal interacting molecule (STIM1) is pivotal for store-operated Ca(2+) entry (SOC). STIM1 proteins sense the Ca(2+) concentration within the lumen of the endoplasmic reticulum (ER) via an EF-hand domain. Dissociation of Ca(2+) from this domain allows fast oligomerization of STIM1 and the formation of spatially discrete clusters close to the plasma membrane. By lifetime-imaging of STIM1 interaction, the rearrangement of STIM1, ER Ca(2+) concentration ([Ca(2+)](ER)) and cytosolic Ca(2+) signals ([Ca(2+)](cyto)) we show that [Ca(2+)](cyto) affects the subcellular distribution of STIM1 oligomers and prevents subplasmalemmal STIM clustering, even if the ER is depleted. These data indicate that [Ca(2+)](cyto), independently of the ER Ca(2+) filling state, crucially tunes the formation and disassembly of subplasmalemmal STIM1 clusters, and, thus, protects cells against Ca(2+) overload resulting from excessive SOC activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.