ArticleBMJ (Clinical research ed.)2008
Effect of illicit direct to consumer advertising on use of etanercept, mometasone, and tegaserod in Canada: controlled longitudinal study.
Article in BMJ (Clinical research ed.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmaceutical policies: effects of policies regulating drug marketing.The Cochrane database of systematic reviews · 2023Pooled it
- Universal Free Contraception Coverage Policy, Out-of-Pocket Payments, and Costs.JAMA health forum · 2026Article
- Universal Pharmacare and Contraceptive Dispensations Among Youth.JAMA pediatrics · 2025Article
- Effect of universal no-cost coverage on use of long-acting reversible contraception and all prescription contraception: population based, controlled, interrupted time series analysis.BMJ (Clinical research ed.) · 2025Article
- Forest conservation effectiveness of community forests may decline in the future: Evidence from Cambodia.PNAS nexus · 2023Article
- Article
- Patient Perception and Clinical Impact of Direct-to-Consumer Advertising in Inflammatory Bowel Disease.Digestive diseases and sciences · 2021Article
- The effects of pricing policy on the prices and supply of low-cost medicines in Shandong, China: evidence from an interrupted time series analysis.BMC public health · 2020Article
- Medicines Information and the Regulation of the Promotion of Pharmaceuticals.Science and engineering ethics · 2019Article
- Direct-to-consumer advertising of prescription medications: what the Canadian medical trainee needs to know.Canadian medical education journal · 2019Article
- The impact of a physician detailing and sampling program for generic atorvastatin: an interrupted time series analysis.Implementation science : IS · 2017Article
- The effect of competing direct-to-consumer advertising campaigns on the use of drugs for benign prostatic hyperplasia: time series analysis.Journal of general internal medicine · 2015Observational
- Associations between cancer-related information seeking and receiving PET imaging for routine cancer surveillance--an analysis of longitudinal survey data.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Article
- Pharmaceutical digital marketing and governance: illicit actors and challenges to global patient safety and public health.Globalization and health · 2013Article
- Global reach of direct-to-consumer advertising using social media for illicit online drug sales.Journal of medical Internet research · 2013Article
- Prevalence and Global Health implications of social media in direct-to-consumer drug advertising.Journal of medical Internet research · 2011Article
- Reforming direct-to-consumer advertising.Nature biotechnology · 2011Article
- Usage, risk, and benefit of weight-loss drugs in primary care.Journal of obesity · 2011Article
- Twelve years' experience with direct-to-consumer advertising of prescription drugs in Canada: a cautionary tale.PloS one · 2009Article
- Should Canada allow direct-to-consumer advertising of prescription drugs?: no.Canadian family physician Medecin de famille canadien · 2009Article
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Authors and funding
3 authors.
Funding
Abstract
objectiveTo assess the impact of direct to consumer advertising of prescription drugs in the United States on Canadian prescribing rates for three heavily marketed drugs-etanercept, mometasone, and tegaserod.
designControlled quasi-experimental study using interrupted time series analysis. POPULATION: Representative sample of 2700 Canadian pharmacies and prescription data from 50 US Medicaid programmes.
main outcome measuresDifferences in number of filled prescriptions per 10,000 population per month between English speaking and French speaking (control) Canadian provinces before and after the start of direct to consumer advertising in the United States.
resultsSpending on direct to consumer advertising for study drugs ranged from $194m to $314m ( pound104m- pound169m; euro131m-euro212m) over the study period. Prescription rates for etanercept and mometasone did not increase in English speaking provinces relative to French speaking controls after the start of direct to consumer advertising. In contrast, tegaserod prescriptions increased 42% (0.56 prescriptions/10,000 residents, 95% confidence interval 0.37 to 0.76) in English speaking provinces immediately after the start of US direct to consumer advertising. Uncontrolled analysis of US Medicaid data showed a larger 56% increase in tegaserod prescriptions. However, this increase did not persist over time in either country, despite continued advertising.
conclusionsExposure to US direct to consumer advertising transiently influenced both Canadian and US prescribing rates for tegaserod, a drug later withdrawn owing to safety concerns. The impact of direct to consumer advertising on drug use seems to be highly variable and probably depends on the characteristics of the advertised drug, the level of exposure to direct to consumer advertising, and the cultural context.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.