ArticleMolecular biology and evolution2008
Analysis of two genomes from the mitochondrion-like organelle of the intestinal parasite Blastocystis: complete sequences, gene content, and genome organization.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Aspects of Genetic Diversity, Host Specificity and Public Health Significance of Single-Celled Intestinal Parasites Commonly Observed in Humans and Mostly Referred to as 'Non-Pathogenic'.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025Review
- Genetic Variation among the Partial Gene Sequences of the Ribosomal Protein Large-Two, the Internal Transcribed Spacer, and the Small Ribosomal Subunit ofMicroorganisms · 2024Article
- Mitochondrial metabolism of the facultative parasite Chilodonella uncinata (Alveolata, Ciliophora).Parasites & vectors · 2023Article
- Establishing a Metabolite Extraction Method to Study the Metabolome ofMolecules (Basel, Switzerland) · 2021Article
- Shared evolutionary footprints suggest mitochondrial oxidative damage underlies multiple complex I losses in fungi.Open biology · 2021Article
- Succinate dehydrogenase gene as a marker for studyingHeliyon · 2020Article
- The Human Gut ColonizerFrontiers in cellular and infection microbiology · 2018Article
- Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis.PLoS biology · 2017Article
- Blastocystis Mitochondrial Genomes Appear to Show Multiple Independent Gains and Losses of Start and Stop Codons.Genome biology and evolution · 2016Article
- Increase number of mitochondrion-like organelle in symptomatic Blastocystis subtype 3 due to metronidazole treatment.Parasitology research · 2016Article
- Draft genome sequence of the intestinal parasite Blastocystis subtype 4-isolate WR1.Genomics data · 2015Article
- Blastocystis, an unrecognized parasite: an overview of pathogenesis and diagnosis.Therapeutic advances in infectious disease · 2013Review
- The mitochondrion-like organelle of Trimastix pyriformis contains the complete glycine cleavage system.PloS one · 2013Article
- Mitochondrial evolution.Cold Spring Harbor perspectives in biology · 2012Review
- Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2012Review
- A machine learning approach to identify hydrogenosomal proteins in Trichomonas vaginalis.Eukaryotic cell · 2012Article
- The organellar genome and metabolic potential of the hydrogen-producing mitochondrion of Nyctotherus ovalis.Molecular biology and evolution · 2011Article
- Adenine nucleotide transporters in organelles: novel genes and functions.Cellular and molecular life sciences : CMLS · 2011Review
- Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite.Genome biology · 2011Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Acquisition of mitochondria by the ancestor of all living eukaryotes represented a crucial milestone in the evolution of the eukaryotic cell. Nevertheless, a number of anaerobic unicellular eukaryotes have secondarily discarded certain mitochondrial features, leading to modified organelles such as hydrogenosomes and mitosomes via degenerative evolution. These mitochondrion-derived organelles have lost many of the typical characteristics of aerobic mitochondria, including certain metabolic pathways, morphological traits, and, in most cases, the organellar genome. So far, the evolutionary pathway leading from aerobic mitochondria to anaerobic degenerate organelles has remained unclear due to the lack of examples representing intermediate stages. The human parasitic stramenopile Blastocystis is a rare example of an anaerobic eukaryote with organelles that have retained some mitochondrial characteristics, including a genome, whereas they lack others, such as cytochromes. Here we report the sequence and comparative analysis of the organellar genome from two different Blastocystis isolates as well as a comparison to other genomes from stramenopile mitochondria. Analysis of the characteristics displayed by the unique Blastocystis organelle genome gives us an insight into the initial evolutionary steps that may have led from mitochondria to hydrogenosomes and mitosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.