ArticleJournal of the Royal Society, Interface2008
DNA and lipid bilayers: self-assembly and insertion.
Article in Journal of the Royal Society, Interface, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Computational Methods for Modeling Lipid-Mediated Active Pharmaceutical Ingredient Delivery.Molecular pharmaceutics · 2025Review
- Computational approaches to lipid-based nucleic acid delivery systems.The European physical journal. E, Soft matter · 2023Review
- HylleraasMD: A Domain Decomposition-Based Hybrid Particle-Field Software for Multiscale Simulations of Soft Matter.Journal of chemical theory and computation · 2023Article
- Formation and Properties of a Self-Assembled Nanoparticle-Supported Lipid Bilayer Probed through Molecular Dynamics Simulations.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- A synthetic enzyme built from DNA flips 10Nature communications · 2018Article
- Structure and electrical properties of DNA nanotubes embedded in lipid bilayer membranes.Nucleic acids research · 2018Article
- Structure and conformational dynamics of scaffolded DNA origami nanoparticles.Nucleic acids research · 2017Article
- Self-Assembly of Amphiphilic Dendrimers: The Role of Generation and Alkyl Chain Length in siRNA Interaction.Scientific reports · 2016Article
- Simulation of lipid bilayer self-assembly using all-atom lipid force fields.Physical chemistry chemical physics : PCCP · 2016Article
- All-atom lipid bilayer self-assembly with the AMBER and CHARMM lipid force fields.Chemical communications (Cambridge, England) · 2015Article
- Structure and properties of DNA in apolar solvents.The journal of physical chemistry. B · 2014Article
- Sidekick for Membrane Simulations: Automated Ensemble Molecular Dynamics Simulations of Transmembrane Helices.Journal of chemical theory and computation · 2014Article
- Peptide-lipid interactions: experiments and applications.International journal of molecular sciences · 2013Article
- All-atom and coarse-grained molecular dynamics simulations of a membrane protein stabilizing polymer.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- Dual-resolution molecular dynamics simulation of antimicrobials in biomembranes.Journal of the Royal Society, Interface · 2011Article
- Molecular dynamics simulations of DNA within a nanopore: arginine-phosphate tethering and a binding/sliding mechanism for translocation.Biochemistry · 2011Article
- Introduction. Biomolecular simulation.Journal of the Royal Society, Interface · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
DNA-lipid complexes are of biomedical importance as delivery vectors for gene therapy. To gain insight into the interactions of DNA with zwitterionic and cationic (dimyristoyltrimethylammonium propane (DMTAP)) lipids, we have used coarse-grained molecular dynamics simulations to study the self-assembly of DPPC and DPPC/DMTAP lipid bilayers in the presence of a DNA dodecamer. We observed the spontaneous formation of lipid bilayers from initial systems containing randomly placed lipids, water-counterions and DNA. In both the DPPC and DPPC/DMTAP simulations, the DNA molecule is located at the water-lipid headgroup interface, lying approximately parallel to the plane of the bilayer. We have also calculated the potential of mean force for transferring a DNA dodecamer through a DPPC/DMTAP bilayer. A high energetic barrier to DNA insertion into the hydrophobic core of the bilayer is observed. The DNA adopts a transmembrane orientation only in this region. Local bilayer deformation in the vicinity of the DNA molecule is observed, largely as a result of the DNA-DMTAP headgroup attraction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.