Evidence map›Paper›PMID 18765214›Full record

ArticleAnesthesiology clinics2008

Genomics: risk and outcomes in cardiac surgery.

Tjorvi E Perry, Jochen D Muehlschlegel, Simon C Body

Abstract read
In one paragraph

Article in Anesthesiology clinics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tjorvi E Perry *Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115.
Jochen D Muehlschlegel *Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115.
Simon C BodyDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115.

Funding

SCHOLARS IN CLINICAL SCIENCE PROGRAMK30RR022292 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WILLIAMS, GORDON H · 2005 to 2007
$900k
Genotypic Impact on Outcomes after CABG SurgeryK23HL068774 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BODY, SIMON C · 2002 to 2006
$803k
NCRR NIH HHS K30 RR022292NHLBI NIH HHS K23 HL068774NHLBI NIH HHS K23 HL68774
6 · The paper itself

Abstract

Coronary artery bypass graft surgery is associated with several frequent postoperative adverse events. Outcome prediction is valued by patients and practitioners, because it provides some measure of balancing risks and benefits and provides expensive or higher-risk therapies to individuals at highest risk. Surgeons and anesthesiologists traditionally have relied on demographic, preoperative, and intraoperative risk factors to predict outcomes after cardiac surgery. Yet, such predictions often have poor positive and negative predictive value for the individual patient. Perioperative genetics attempts to determine the impact of an individual's genetic variation on the risk of developing adverse postoperative outcomes. In this article, the authors discuss emerging evidence that a patient's genetic makeup predisposes him or her to adverse outcomes following cardiac surgery and provide examples from perioperative bleeding, myocardial injury/infarction, and atrial fibrillation.

Indexed as

Cardiac Surgical ProceduresGenetic VariationAtrial FibrillationBlood PlateletsComplement ActivationHemorrhageHumansMyocardial InfarctionOutcome Assessment, Health CarePerioperative CarePlatelet Membrane GlycoproteinsRisk FactorsPlatelet Membrane Glycoproteins

Identifiers

PMID18765214
PMCPMC2744392

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.