ReviewPediatric transplantation2008
The proteogenomic path towards biomarker discovery.
Review in Pediatric transplantation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics: a systematic review.Journal of cellular and molecular medicine · 2017Pooled it
- Elucidating the nexus between onco-immunology and kidney transplantation: An insight from precision medicine perspective.Heliyon · 2024Review
- Methods for Proteogenomics Data Analysis, Challenges, and Scalability Bottlenecks: A Survey.IEEE access : practical innovations, open solutions · 2021Article
- Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients.Journal of clinical medicine · 2020Article
- Article
- Putative Protein Biomarkers ofBiology · 2020Article
- Bioinformatics for Renal and Urinary Proteomics: Call for Aggrandization.International journal of molecular sciences · 2020Review
- Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR.Journal of clinical medicine · 2018Article
- Mining the human urine proteome for monitoring renal transplant injury.Kidney international · 2016Article
- Characterisation of the circulating acellular proteome of healthy sheep using LC-MS/MS-based proteomics analysis of serum.Proteome science · 2016Article
- High-dose immunosuppressant alters the immunological status of New Zealand white rabbits following skin transplantation.Experimental and therapeutic medicine · 2015Article
- Computational Models for Transplant Biomarker Discovery.Frontiers in immunology · 2015Review
- Molecular monitoring of alloimmune-mediated injury in kidney transplant patients.Current opinion in nephrology and hypertension · 2014Review
- Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas.BMC medical genomics · 2014Article
- Recipients with in utero induction of tolerance upregulated MHC class I in the engrafted donor skin.Disease markers · 2014Article
- Article
- The Rice Proteogenomics Database OryzaPG-DB: Development, Expansion, and New Features.Frontiers in plant science · 2012Article
- Recent advances in biomarker discovery in solid organ transplant by proteomics.Expert review of proteomics · 2011Review
- Applications of translational bioinformatics in transplantation.Clinical pharmacology and therapeutics · 2011Article
- Searching for the noninvasive biomarker holy grail: are urine proteomics the answer?Biological research for nursing · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The desire for biomarkers for diagnosis and prognosis of diseases has never been greater. With the availability of genome data and an increased availability of proteome data, the discovery of biomarkers has become increasingly feasible. However, the task is daunting and requires collaborations among researchers working in the fields of transplantation, immunology, genetics, molecular biology, biostatistics and bioinformatics. With the advancement of high throughput omic techniques such as genomics and proteomics (collectively known as proteogenomics), efforts have been made to develop diagnostic tools from new and to-be discovered biomarkers. Yet biomarker validation, particularly in organ transplantation, remains challenging because of the lack of a true gold standard for diagnostic categories and analytical bottlenecks that face high-throughput data deconvolution. Even though microarray technique is relatively mature, proteomics is still growing with regards to data normalization and analysis methods. Study design, sample selection and rigorous data analysis are the critical issues for biomarker discovery using high-throughput proteogenomic technologies that combine the use and strengths of both genomics and proteomics. In this review, we look into the current status and latest developments in the field of biomarker discovery using genomics and proteomics related to organ transplantation, with an emphasis on the evolution of proteomic technologies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.