Evidence map›Paper›PMID 18763817›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2008

Interactions of poly(amidoamine) dendrimers with Survanta lung surfactant: the importance of lipid domains.

Blake Erickson, Stassi C DiMaggio, Douglas G Mullen, Christopher V Kelly, Pascale R Leroueil, Stephanie A Berry, James R Baker, Bradford G Orr, Mark M Banaszak Holl

Open access · greenAbstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Blake EricksonProgram in Biophysics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Stassi C DiMaggio
Douglas G Mullen
Christopher V Kelly
Pascale R Leroueil
Stephanie A Berry
James R Baker
Bradford G Orr
Mark M Banaszak Holl
University of Michigan–Ann Arbor · USXavier University · US

Funding

MICHIGAN MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008270 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, CHARLES L · 1988 to 2012
$4.5M
The Role of Cell Membrane Disruption in Non-Viral Vector Oligonucleotide DeliveryR01EB005028 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BANASZAK HOLL, MARK M · 2006 to 2013
$2.8M
NIBIB NIH HHS R01 EB005028NIBIB NIH HHS R01-EB005028NIGMS NIH HHS T32 GM008270NIGMS NIH HHS T32 GM008270-20
6 · The paper itself

Abstract

The interaction of generation 5 (G5) and 7 (G7) poly(amidoamine) (PAMAM) dendrimers with mica-supported Survanta bilayers is studied with atomic force microscopy (AFM). In these experiments, Survanta forms distinct gel and fluid domains with differing lipid composition. Nanoscale defects are induced by the PAMAM dendrimers. The positively charged dendrimers remove lipid from the fluid domains at a significantly greater rate than for the gel domains. Dendrimer accumulation on lipid edges and terraces preceding lipid removal has been directly imaged. Immediately following lipid removal, the mica surface is clean, indicating that lipid defects are not induced by dendrimers binding to the mica substrate and displacing the lipid.

Indexed as

Biological ProductsDendrimersFatty AcidsLipidsMicroscopy, Atomic ForceModels, ChemicalMolecular StructurePolyaminesProteinsPulmonary SurfactantsberactantBiological ProductsDendrimersFatty AcidsLipidsPoly(amidoamine)PolyaminesProteinsPulmonary Surfactants

Identifiers

PMID18763817
PMCPMC2917325
OpenAlexW2057101596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.