Evidence map›Paper›PMID 18763762›Full record

ArticleJournal of the American Chemical Society2008

Selecting aptamers for a glycoprotein through the incorporation of the boronic acid moiety.

Minyong Li, Na Lin, Zhen Huang, Lupei Du, Craig Altier, Hao Fang, Binghe Wang

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
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  17. Inside the Black Box: What Makes SELEX Better?Molecules (Basel, Switzerland) · 2019
    Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minyong LiDepartment of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30302-4098, USA.
Na Lin
Zhen Huang
Lupei Du
Craig Altier
Hao Fang
Binghe Wang

Funding

Selection of Boronic Acid-modified Aptamers for GlycoproteinsR01GM084933 · NIGMS · GEORGIA STATE UNIVERSITY · PI WANG, BINGHE · 2008 to 2011
$1.2M
Fluorescent Aptamers for Glycoprotein DetectionR21CA113917 · NCI · GEORGIA STATE UNIVERSITY · PI WANG, BINGHE · 2005 to 2006
$366k
MRI contrast agents targeting carbohydrate biomarkersR21CA123329 · NCI · GEORGIA STATE UNIVERSITY · PI WANG, BINGHE · 2006 to 2007
$357k
NCI NIH HHS CA113917NCI NIH HHS CA123329NCI NIH HHS R21 CA113917NCI NIH HHS R21 CA123329NIGMS NIH HHS GM084933NIGMS NIH HHS R01 GM084933
6 · The paper itself

Abstract

The first general method for the selection of boronic acid-based aptamers (boronolectins) that allows for glycan substructure focusing is described. Using fibrinogen as a model glycoprotein, we have selected boronic acid-modified DNA aptamers that have high affinities (low nM Kd) and the ability to recognize changes in the glycosylation site. The method developed should also be applicable to the development of aptamers for other glycoproducts, such as glycolipids and glycopeptides.

Indexed as

Aptamers, NucleotideBoronic AcidsCloning, MolecularEscherichia coliFibrinogenGene LibraryGlycoproteinsGlycosylationImmobilized ProteinsKineticsLigandsPolysaccharidesSELEX Aptamer TechniqueAptamers, NucleotideBoronic AcidsFibrinogenGlycoproteinsImmobilized ProteinsLigandsPolysaccharides

Identifiers

PMID18763762
PMCPMC2655352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.