ArticleWorld journal of gastroenterology2008
Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males.
Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Association ofBioscience reports · 2019Pooled it
- Pooled it
- Association between ALDHAfrican health sciences · 2017Pooled it
- Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis.PloS one · 2015Pooled it
- Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk.PloS one · 2014Pooled it
- Association between alcohol consumption and cancers in the Chinese population--a systematic review and meta-analysis.PloS one · 2011Pooled it
- Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study.Scientific reports · 2016Trial
- Carcinogenicity of vinyl acetate: evidence from multiple data streams.Environmental health : a global access science source · 2025Review
- ALDH2 gene rs671 G > a polymorphism and the risk of colorectal cancer: A hospital-based study.Journal of clinical laboratory analysis · 2022Article
- Genome-wide association study of colorectal polyps identified highly overlapping polygenic architecture with colorectal cancer.Journal of human genetics · 2022Article
- Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective.International journal of environmental research and public health · 2021Review
- Review
- A critical analysis of the relationship between aldehyde dehydrogenases-2 Glu487Lys polymorphism and colorectal cancer susceptibility.Pathology oncology research : POR · 2015Article
- Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation.British journal of pharmacology · 2013Article
- Article
- Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer.PloS one · 2013Article
- A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer.Experimental and therapeutic medicine · 2012Article
- The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese.Human genomics · 2011Article
- ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications.Pharmacology & therapeutics · 2011Review
- Changes in aldehyde dehydrogenase 2 expression in rat blood vessels during glyceryl trinitrate tolerance development and reversal.British journal of pharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males.
methodsA case-control study was conducted in 190 cases and 223 population-based controls. ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A) genotypes were identified by PCR and denaturing high-performance liquid chromatography (DHPLC). Information on smoking and drinking was collected and odds ratio (OR) was estimated.
resultsThe ADH2 A/A and ALDH2 G/G genotypes showed moderately increased CRC risk. The age- and smoking-adjusted OR for ADH2 A/A relative to G/A and G/G was 1.60 (95% CI=1.08-2.36), and the adjusted OR for ALDH2 G/G relative to G/A and A/A was 1.79 (95% CI=1.19-2.69). Significant interactions between ADH2, ALDH2 and drinking were observed. As compared to the subjects with ADH2 G and ALDH2 A alleles, those with ADH2 A/A and ALDH2 G/G genotypes had a significantly increased OR (3.05, 95% CI= 1.67-5.57). The OR for CRC among drinkers with the ADH2 A/A genotype was increased to 3.44 (95% CI= 1.84-6.42) compared with non-drinkers with the ADH2 G allele. The OR for CRC among drinkers with the ALDH2 G/G genotype was also increased to 2.70 (95% CI= 1.57-4.66) compared with non-drinkers with the ALDH2 A allele.
conclusionPolymorphisms of the ADH2 and ALDH2 genes are significantly associated with CRC risk. There are also significant gene-gene and gene-environment interactions between drinking and ADH2 and ALDH2 polymorphisms regarding CRC risk in Chinese males.
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