ArticleJournal of clinical immunology2009
Proinflammatory cytokine gene polymorphisms among Iranian patients with asthma.
Article in Journal of clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06176742 (Comparative Effects of Active Cycle Breathing Technique and Bubble Positive Expiratory Pressure Device in Asthmatic Patients), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effects of Active Cycle Breathing Technique and Bubble Positive Expiratory Pressure Device in Asthmatic Patients
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effects ofFrontiers in genetics · 2022Pooled it
- Association between polymorphism of interleukin-1 beta and interleukin-1 receptor antagonist gene and asthma risk: a meta-analysis.TheScientificWorldJournal · 2015Pooled it
- Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.PloS one · 2014Pooled it
- The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.Journal of clinical immunology · 2011Pooled it
- Association ofIranian journal of public health · 2020Review
- Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure.Acta bio-medica : Atenei Parmensis · 2019Article
- Cytokine Gene Polymorphisms in Saudi Patients With Atopic Dermatitis: A Case-Control Study.Biomarker insights · 2018Article
- Article
- Interleukin 6 SNP rs1800797 associates with the risk of adult-onset asthma.Genes and immunity · 2016Article
- Lack of association between interleukin-10, transforming growth factor-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus.Clinical rheumatology · 2015Article
- Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2015Article
- Relationship between interleukin-1 type 1 and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors.Cellular & molecular immunology · 2015Article
- Interleukin-6 gene -174G/C polymorphism and bronchial asthma risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Gene susceptibility in Iranian asthmatic patients: a narrative review.Annals of medical and health sciences research · 2014Review
- Investigation of interleukin-10 promoter polymorphisms and interleukin-10 levels in children with irritable bowel syndrome.Gut and liver · 2013Article
- T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome.Inflammation · 2010Article
- Importance of cytokines in murine allergic airway disease and human asthma.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
- Proinflammatory cytokine gene polymorphisms in irritable bowel syndrome.Journal of clinical immunology · 2010Article
- IL-2, IFN-gamma, and IL-12 gene polymorphisms and susceptibility to multiple sclerosis.Journal of clinical immunology · 2009Article
- STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma.International journal of biological sciences · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAsthma is one of the most common respiratory diseases caused by acute and chronic inflammation of airways. Proinflammatory cytokines could contribute to this inflammatory process. This study was performed in order to analyze the genetic profile of proinflammatory cytokines in Iranian asthmatic patients. PATIENTS AND
methodsThe allele and genotype frequencies of a number polymorphic genes coding for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-1 receptor (IL-1R), IL-1RA, and IL-6 were investigated in 60 patients with asthma in comparison with 140 controls using polymerase chain reaction with sequence-specific primers.
resultsThe most frequent genotypes in our patients were TNF-alpha GA at position -308 (P = 0.001), TNF-alpha AA at position -238 (P = 0.01), IL-1 alpha TC at position -889 (P = 0.0001), IL-1 beta TC at position -511 (P = 0.0001), and IL-1RA TC at position Mspa-I 11100 (P = 0.001). In contrast, the frequencies of the genotypes TNF-alpha GG at position -308 (P = 0.001), IL-1 alpha CC at position -889 (P = 0.005), IL-1 beta CC at position -511 (P = 0.0001), and IL-1RA TT at position Mspa-I 11100 (P = 0.0001) in the patient group were significantly lower than controls. The most frequent haplotypes for TNF-alpha (positions 308, -238) was A/A in the patient group in comparison with controls (P = 0.0001).
conclusionWhile environmental factors are important in the development of asthma, genetic factors could have a critical role in the expression of the disease. Considering the high frequency of presence of TNF-alpha AG genotype (-308), it seems that the production of TNF-alpha in the asthmatic patients could be higher than normal subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.