ArticlePflugers Archiv : European journal of physiology2009
Large-conductance calcium-dependent potassium channels prevent dendritic excitability in neocortical pyramidal neurons.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Fibronectin1-Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intrinsic Dendritic Integration Features of Prefrontal Layer 5 Pyramidal Cell Subclasses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Defects of Cortical Microcircuits Following Early Exposure to Alcohol.Advances in experimental medicine and biology · 2025Review
- Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024Review
- CaInternational journal of molecular sciences · 2023Review
- Paradoxical Excitatory Impact of SK Channels on Dendritic Excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Impact of calcium-activated potassium channels on NMDA spikes in cortical layer 5 pyramidal neurons.Journal of neurophysiology · 2016Article
- The Impact of BK Channels on Cellular Excitability Depends on their Subcellular Location.Frontiers in cellular neuroscience · 2016Article
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
- Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion.The Journal of physiology · 2015Article
- Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron.Frontiers in cellular neuroscience · 2015Review
- Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-/y) mice.Nature neuroscience · 2014Article
- BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons.Brain research · 2014Article
- Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior.Frontiers in physiology · 2014Review
- Article
- Properties of BK-type Ca(+) (+)-dependent K(+) channel currents in medial prefrontal cortex pyramidal neurons in rats of different ages.Frontiers in cellular neuroscience · 2013Article
- Duration differences of corticostriatal responses in striatal projection neurons depend on calcium activated potassium currents.Frontiers in systems neuroscience · 2013Article
- Article
- P/Q and N channels control baseline and spike-triggered calcium levels in neocortical axons and synaptic boutons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-conductance calcium-dependent potassium channels (BK channels) are homogeneously distributed along the somatodendritic axis of layer 5 pyramidal neurons of the rat somatosensory cortex. The relevance of this conductance for dendritic calcium electrogenesis was studied in acute brain slices using somatodendritic patch clamp recordings and calcium imaging. BK channel activation reduces the occurrence of dendritic calcium spikes. This is reflected in an increased critical frequency of somatic spikes necessary to activate the distal initiation zone. Whilst BK channels repolarise the somatic spike, they dampen it only in the distal dendrite. Their activation reduces dendritic calcium influx via glutamate receptors. Furthermore, they prevent dendritic calcium electrogenesis and subsequent somatic burst discharges. However, the time window for coincident somatic action potential and dendritic input to elicit dendritic calcium events is not influenced by BK channels. Thus, BK channel activation in layer 5 pyramidal neurons affects cellular excitability primarily by establishing a high threshold at the distal action potential initiation zone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.