ArticleInternational journal of colorectal disease2009
Polymorphisms of the macrophage inflammatory protein 1 alpha and ApoE genes are associated with ulcerative colitis.
Article in International journal of colorectal disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Systematic Investigation of the Efficacy of Sinitang Decoction Against Ulcerative Colitis.Frontiers in pharmacology · 2020Article
- Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis.World journal of gastroenterology · 2018Article
- Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice.World journal of gastroenterology · 2018Article
- Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice.Inflammatory bowel diseases · 2016Article
- Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease.World journal of gastroenterology · 2015Article
- The therapeutic benefits of epigallocatechin gallate in rats with experimentally induced ulcerative colitis are achieved by influencing inflammation and apoptosis.Annals of gastroenterologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAn increased production of macrophage inflammatory proteins 1 alpha (MIP-1alpha) has been reported to be associated with ulcerative colitis (UC). We investigated whether a polymorphism site in MIP-1alpha was associated with UC in a Chinese population. Additionally, considering the abnormal lipoprotein metabolism in subjects with UC, we also sought to determine whether genetic variation in the apolipoprotein E (ApoE) gene may play a role in the development of UC. MATERIALS AND
methodsWe examined the MIP-1alpha -906 (TA)(4)/(TA)(6) polymorphism and the ApoE polymorphism in a cohort of 162 unrelated UC patients and 220 healthy controls by using restriction fragment length polymorphism assay.
resultsA significantly increased frequency of the MIP-1alpha -906 (TA)(6)/(TA)(6) genotype (P = 0.0031, odds ratio [OR] = 1.851, 95% confidence interval [CI] 1.228-2.791), as well as of the ApoE epsilon4+ genotype (P < 0.001, OR = 2.869, 95% CI 1.768-4.657), in patients with UC was proven. Moreover, the carriage of both MIP-1alpha -906 (TA)(6)/(TA)(6) genotype and ApoE epsilon4+ genotype confers greater risk for the development of UC (P < 0.001, OR = 5.432, 95% CI 2.761-10.689).
conclusionThese findings suggest that variation in the MIP-1alpha and ApoE genes and their interaction may increase susceptibility to UC. Identifying these novel susceptibility genes, as well as their interactions, will help our understanding of the disease mechanisms of UC and may identify targets for developing novel treatment measures.
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