ArticleWorld journal of urology2009
Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury.
Article in World journal of urology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- HMG-CoA reductase inhibition preserves testicular function after torsion/detorsion by modulating oxidative stress and AKT signaling.Scientific reports · 2025Article
- Molecular Mechanisms of Testis Damage and Target Drug Development in the Ischemic-Reperfusion Injury of Acute Testicular Torsion: A Pediatric Urological Perspective.The world journal of men's health · 2025Article
- Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models.Heliyon · 2024Review
- The navel nanoethosomal formulation of gamma-oryzanol attenuates testicular ischemia/reperfusion damages.Heliyon · 2024Article
- Effects of acetylsalicylic acid and ultrasound elastography on testicular torsion in rats.Turkish journal of medical sciences · 2023Article
- Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia/reperfusion in rats: a comparative study.BMC pharmacology & toxicology · 2022Article
- A narrative review of the protective effects of curcumin in treating ischemia-reperfusion injury.Annals of translational medicine · 2022Review
- Testicular torsions in veterinary medicine.Veterinary research communications · 2022Review
- Leech therapy (Hirudo medicinalis) attenuates testicular damages induced by testicular ischemia/reperfusion in an animal model.BMC veterinary research · 2021Article
- The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.Acta cirurgica brasileira · 2020Article
- Medical perspective in testicular ischemia-reperfusion injury.Experimental and therapeutic medicine · 2017Article
- The effect of antioxidant supplementation on bacterial translocation after intestinal ischemia and reperfusion.Redox report : communications in free radical research · 2017Review
- Mechanisms of testicular torsion and potential protective agents.Nature reviews. Urology · 2014Review
- Protective effects of lipoxin A4 in testis injury following testicular torsion and detorsion in rats.Mediators of inflammation · 2014Article
- The hypoxic testicle: physiology and pathophysiology.Oxidative medicine and cellular longevity · 2012Review
- Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion.Clinics (Sao Paulo, Brazil) · 2011Article
- Vardenafil reduces testicular damage following ischemia/reperfusion injury in rats.The Kaohsiung journal of medical sciences · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTrapidil is an antianginal compound with a broad spectrum of pharmacological activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. We evaluated the effect of trapidil on the long-term histologic damage in testicular ischemia-reperfusion injury.
methodsAdult male Wistar rats were divided into three groups of six rats each. One group underwent 2 h of testicular torsion; one received pretreatment with trapidil before detorsion; and one group underwent sham operation. All rats underwent bilateral orchiectomy 60 days after the experiment. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histological examination of each testis.
resultsTesticular torsion-detorsion caused a significant decrease in the mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score in the ipsilateral testes, but not in the contralateral testes. The animals treated with trapidil had a significant increase in these histological parameters as compared to the torsion-detorsion group.
conclusionTrapidil administration before reperfusion may have the potential to decrease the long-term histologic damage that occurs after experimental testicular torsion. Trapidil is used as an antianginal drug and additional clinical studies are required to elucidate the protective role of trapidil in patients with testicular torsion.
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