ArticleProstate cancer and prostatic diseases2009
Biopsy tissue microarray study of Ki-67 expression in untreated, localized prostate cancer managed by active surveillance.
Article in Prostate cancer and prostatic diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Active surveillance for prostate cancer: a systematic review of clinicopathologic variables and biomarkers for risk stratification.European urology · 2015Pooled it
- Evaluation of the Proliferation Marker Ki-67 for Improved Risk Stratification of Prostate Cancer Patients Under Active Surveillance.Diagnostics (Basel, Switzerland) · 2026Article
- Novel concepts for risk stratification in prostate cancer.Journal of clinical urology · 2016Article
- Incorporation of tissue-based genomic biomarkers into localized prostate cancer clinics.BMC medicine · 2016Review
- [Prostate cancer. Part 1: Review of cell kinetics over the years 1966-2015 and future perspectives of the new grading of the International Society of Urological Pathology (ISUP)].Der Pathologe · 2016Review
- Comparison of digital image analysis and visual scoring of KI-67 in prostate cancer prognosis after prostatectomy.Diagnostic pathology · 2015Article
- Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer.Advances in experimental medicine and biology · 2014Article
- Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.British journal of cancer · 2013Article
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- High-density tissue microarrays from prostate needle biopsies.Journal of clinical pathology · 2011Article
- Novel diagnostic biomarkers for prostate cancer.Journal of Cancer · 2010Article
- Cancer biomarker discovery: the entropic hallmark.PloS one · 2010Article
- Serum micronutrient and antioxidant levels at baseline and the natural history of men with localised prostate cancer on active surveillance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2010Article
- Pro-prostate-specific antigen measurements in serum and tissue are associated with treatment necessity among men enrolled in expectant management for prostate cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- An improved method for constructing tissue microarrays from prostate needle biopsy specimens.Journal of clinical pathology · 2009Article
- Contemporary Strategies for Clinical Chemoprevention of Localized Prostate Cancer.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Active surveillance provides a unique opportunity to study biomarkers of prostate cancer behaviour, although only small volumes of tumor tissue are typically available. We have evaluated a technique for constructing tissue microarrays (TMAs) from needle biopsies for assessing immunohistochemical markers in localized prostate cancer managed by active surveillance. TMAs were constructed from diagnostic prostate biopsies for 60 patients with localized prostatic adenocarcinoma in a prospective cohort study of active surveillance. Radical treatment was recommended for a prostate-specific antigen (PSA) velocity greater than 1 ng ml(-1) per year or adverse histology in repeat biopsies, defined as Gleason score > or =4+3 or >50% of cores involved. Sections from the TMAs were stained with H&E, P63/AMACR and Ki-67. Time to radical treatment was analysed with respect to clinical characteristics and Ki-67 LI. At a median follow up of 36 months, 25/60 (42%) patients had received radical treatment. On univariate analysis, PSA density (P=0.001), Gleason score (P=0.001), clinical T stage (P=0.01), Ki-67 LI (P=0.02) and initial PSA (P=0.04) were associated with time to radical treatment. On multivariate analysis, PSA density (P=0.01), Ki-67 LI (P=0.03) and Gleason score (P=0.04) were independent determinants of progression to radical treatment. TMAs constructed from prostate needle biopsies can be used to assess immunohistochemical markers in localized prostate cancer managed by active surveillance. Ki-67 LI merits further study as a possible biomarker of early prostate cancer behaviour.
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