ArticleMolecular psychiatry2010
Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Article in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Alterations in brain synaptic proteins and mRNAs in mood disorders: a systematic review and meta-analysis of postmortem brain studies.Molecular psychiatry · 2022Pooled it
- Meta-analysis of expression and methylation signatures indicates a stress-related epigenetic mechanism in multiple neuropsychiatric disorders.Translational psychiatry · 2019Pooled it
- Multi-omics and electrophysiological examination of GABAMolecular psychiatry · 2026Article
- Reverse phase protein array-based investigation of mitochondrial genes reveals alteration of glutaminolysis in the parahippocampal cortex of people who died by suicide.Translational psychiatry · 2024Article
- The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials.International journal of molecular sciences · 2024Review
- The long noncoding RNA FEDORA is a cell type- and sex-specific regulator of depression.Science advances · 2022Article
- Insights into myelin dysfunction in schizophrenia and bipolar disorder.World journal of psychiatry · 2022Review
- Understanding the Links among Maternal Diet, Myelination, and Depression: Preclinical and Clinical Overview.Cells · 2022Review
- Article
- Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Review
- Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex.Translational psychiatry · 2018Article
- Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders.Frontiers in molecular neuroscience · 2018Review
- Role of Dopamine D2 Receptor in Stress-Induced Myelin Loss.Scientific reports · 2017Article
- Chronic social defeat reduces myelination in the mouse medial prefrontal cortex.Scientific reports · 2017Article
- Neuropathology of mood disorders: do we see the stigmata of inflammation?Translational psychiatry · 2016Review
- Altered metabolic activity in the developing brain of rats predisposed to high versus low depression-like behavior.Neuroscience · 2016Article
- Differential activation of immune/inflammatory response-related co-expression modules in the hippocampus across the major psychiatric disorders.Molecular psychiatry · 2016Article
- A review of Rett syndrome (RTT) with induced pluripotent stem cells.Stem cell investigation · 2016Review
- Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia.Translational neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoarchitectural abnormalities have been described in the prefrontal cortex of subjects with schizophrenia, bipolar disorder and depression. However, little is known about the gene expression profiles associated with these abnormalities. Genome-wide expression profiling technology provides an unbiased approach to identifying candidate genes and biological processes that may be associated with complex biological traits such as cytoarchitecture. In this study, we explored expression profiles associated with the abnormalities by using publicly available microarray metadata and cytoarchitectural data from post-mortem samples of the frontal cortex from 54 subjects (schizophrenia, n=14; bipolar disorder, n=13; depression, n=12 and controls n=15). Correlation analysis between genome-wide expression levels and cytoarchitectural traits revealed that 818 genes were significantly correlated with a decrease in the number of perineuronal oligodendrocytes across all subjects. A total of 600 genes were significantly correlated with a decrease in density of calbindin-positive interneurons across all subjects. Multiple biological processes including cellular metabolism, central nervous system development, cell motility and programmed cell death were significantly overrepresented in both correlated gene lists. These findings may provide novel insights into the molecular mechanisms that underlie the cytoarchitectural abnormalities of perineuronal oligodendrocytes and calbindin-containing GABAergic interneurons in the prefrontal cortex of the major psychiatric disorders.
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