ArticleThe Journal of experimental medicine2008
Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity.
Article in The Journal of experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 134 citations in OpenAlex.
- Pneumococcal conjugate vaccination at birth in a high-risk setting: no evidence for neonatal T-cell tolerance.Vaccine · 2011Trial
- Sex differences in the effects of maternal vitamin supplements on mortality and morbidity among children born to HIV-infected women in Tanzania.The British journal of nutrition · 2010Trial
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- Vaccine Responses in Early Age.Vaccines · 2026Review
- The Role and Safety of Aluminum Adjuvants in Childhood Vaccines.Pediatrics · 2026Review
- Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.Mucosal immunology · 2025Review
- Calcium signaling is essential for T helper 1 cell differentiation.Nature immunology · 2025Article
- STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TNature immunology · 2025Article
- Interferons-Implications in the Immune Response to Respiratory Viruses.Microorganisms · 2023Review
- Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs.Science immunology · 2023Article
- The Neonatal Immune System and Respiratory Pathogens.Microorganisms · 2023Review
- TLR agonists induce sustained IgG to hemagglutinin stem and modulate T cells following newborn vaccination.NPJ vaccines · 2022Article
- Differences in H3K4me3 and chromatin accessibility contribute to altered T-cell receptor signaling in neonatal naïve CD4 T cells.Immunology and cell biology · 2022Article
- Immunopathogenesis of patients with COVID-19: from the perspective of immune system 'evolution' and 'revolution'.Expert reviews in molecular medicine · 2022Review
- Neonatal Immune Responses to Respiratory Viruses.Frontiers in immunology · 2022Review
- Understanding Antibody Responses in Early Life: Baby Steps towards Developing an Effective Influenza Vaccine.Viruses · 2021Review
- Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.Nature communications · 2021Article
- Influence of Nutrition and Maternal Bonding on Postnatal Lung Development in the Newborn Pig.Frontiers in immunology · 2021Article
- Age-Related Changes in Thymic Central Tolerance.Frontiers in immunology · 2021Review
- Strategies for active and passive pediatric RSV immunization.Therapeutic advances in vaccines and immunotherapy · 2021Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Primary neonatal T cell responses comprise both T helper (Th) cell subsets, but Th1 cells express high levels of interleukin 13 receptor alpha1 (IL-13R alpha 1), which heterodimerizes with IL-4R alpha. During secondary antigen challenge, Th2-produced IL-4 triggers the apoptosis of Th1 cells via IL-4R alpha/IL-13R alpha 1, thus explaining the Th2 bias in neonates. We show that neonates acquire the ability to overcome the Th2 bias and generate Th1 responses starting 6 d after birth. This transition was caused by the developmental maturation of CD8 alpha(+)CD4(-) dendritic cells (DCs), which were minimal in number during the first few days of birth and produced low levels of IL-12. This lack of IL-12 sustained the expression of IL-13R alpha 1 on Th1 cells. By day 6 after birth, however, a significant number of CD8 alpha(+)CD4(-) DCs accumulated in the spleen and produced IL-12, which triggered the down-regulation of IL-13R alpha 1 expression on Th1 cells, thus protecting them against IL-4-driven apoptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.