Trial reportPediatrics2008
A randomized trial of nicotine nasal spray in adolescent smokers.
Trial report in Pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Nicotine replacement therapy as a smoking cessation tool for adolescents: an update.Frontiers in psychiatry · 2025Pooled it
- Nicotine replacement therapy versus control for smoking cessation.The Cochrane database of systematic reviews · 2018Pooled it
- Tobacco cessation interventions for young people.The Cochrane database of systematic reviews · 2017Pooled it
- Efficacy and Safety of Varenicline for Adolescent Smoking Cessation: A Randomized Clinical Trial.JAMA pediatrics · 2019Trial
- Varenicline versus bupropion XL for smoking cessation in older adolescents: a randomized, double-blind pilot trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Trial
- Bupropion SR and contingency management for adolescent smoking cessation.Journal of substance abuse treatment · 2011Trial
- Helping teens quit: A systematic review and network meta-analysis of smoking cessation interventions.Public health in practice (Oxford, England) · 2026Review
- Effects of tobacco product use on oral health and the role of oral healthcare providers in cessation: A narrative review.Tobacco induced diseases · 2023Review
- TOBACCO USE DISORDER AND DUAL DISORDERS Joint statement by the Spanish Psychiatry Society and the Spanish Dual Disorders Society.Actas espanolas de psiquiatria · 2022Article
- Nicotine replacement therapy: A friend or foe.Journal of family medicine and primary care · 2020Review
- Urinary 11-nor-9-carboxy-tetrahydrocannabinol elimination in adolescent and young adult cannabis users during one month of sustained and biochemically-verified abstinence.Journal of psychopharmacology (Oxford, England) · 2020Article
- Pharmacological Treatment of Youth Substance Use Disorders.Journal of child and adolescent psychopharmacology · 2019Review
- The Role of Pharmacotherapy in the Treatment of Adolescent Substance Use Disorders.Child and adolescent psychiatric clinics of North America · 2016Review
- Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate.Biological psychiatry · 2016Article
- Emerging Pharmacologic Treatments for Adolescent Substance Use: Challenges and New Directions.Current addiction reports · 2016Article
- Pharmacotherapy for Substance Use Disorders in Youths.Journal of child & adolescent substance abuse · 2016Article
- Staying Young at Heart: Cardiovascular Disease Prevention in Adolescents and Young Adults.Current treatment options in cardiovascular medicine · 2015Article
- Formulation of nicotine mucoadhesive tablet for smoking cessation and evaluation of its pharmaceuticals properties.Advanced biomedical research · 2013Article
- Efficacy and tolerability of pharmacotherapies to aid smoking cessation in adolescents.Paediatric drugs · 2012Review
- Smoking cessation treatment for adolescents.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2010Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesNicotine nasal spray has been 1 of the most successful forms of nicotine-replacement therapy in adult populations. The nasal sprayer has not been studied in adolescent smokers. The objective of this pilot study was to determine the feasibility and utility of using nicotine nasal spray for adolescent smokers who wanted to quit smoking.
methodsForty adolescent smokers who were between 15 and 18 years of age and smoked >/=5 cigarettes daily for at least 6 months were recruited from several San Francisco Bay area schools from 2005 to 2007. Using a randomized, open-label, 12-week trial, adolescent smokers were assigned to receive either weekly counseling alone (control) for 8 weeks or 8 weeks of counseling along with 6 weeks of nicotine nasal spray. Self-reported smoking abstinence was verified by both expired-air carbon monoxide and salivary cotinine.
resultsThere was no difference in cessation rates, the numbers of cigarettes smoked per day, or cotinine levels at 12 weeks. Fifty-seven percent of participants stopped using their spray after only 1 week. The most commonly reported adverse effect was nasal irritation and burning (34.8%) followed by complaints about the taste and smell (13%).
conclusionsThe unpleasant adverse effects, poor adherence, and consequent lack of efficacy observed in our pilot study do not support the use of nicotine nasal spray as an adjunct to counseling for adolescent smokers who wish to quit.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.