ArticleCellular immunology2009
Calcineurin-dependent lytic granule exocytosis in NK-92 natural killer cells.
Article in Cellular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Trial
- Characterization of immune phenotypes in peripheral blood of adult renal transplant recipients using mass cytometry (CyTOF).ImmunoHorizons · 2025Article
- Heterogeneity in IgG-CD16 signaling in infectious disease outcomes.Immunological reviews · 2022Review
- Acoustofluidic Stimulation of Functional Immune Cells in a Microreactor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Toward a Better Understanding of Bioassays for the Development of Biopharmaceuticals by Exploring the Structure-Antibody-Dependent Cellular Cytotoxicity Relationship in Human Primary Cells.Frontiers in immunology · 2020Article
- Small-Molecule Immunosuppressive Drugs and Therapeutic Immunoglobulins Differentially Inhibit NK Cell Effector FunctionsFrontiers in immunology · 2019Article
- Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis.Journal of biomolecular screening · 2013Article
- Two modes of lytic granule fusion during degranulation by natural killer cells.Immunology and cell biology · 2011Article
- Consecutive low doses of cyclosporine A induce pro-inflammatory cytokines and accelerate allograft skin rejection.Molecules (Basel, Switzerland) · 2011Article
- FK506 causes cellular and functional defects in human natural killer cells.Journal of leukocyte biology · 2010Article
- Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo.PloS one · 2010Article
- Calcineurin-mediated dephosphorylation of synaptotagmin VI is necessary for acrosomal exocytosis.The Journal of biological chemistry · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cytotoxic T cells (CTLs) and natural killer cells (NKs) both kill virus-infected cells and tumor cells by releasing the cytoxic contents of their lytic granules. We recently demonstrated a role for calcineurin in lytic granule exocytosis in TALL-104 human leukemic CTLs [M.J. Grybko, J.P. Bartnik, G.A. Wurth, A.T. Pores-Fernando, A. Zweifach, Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis, J. Biol. Chem. 282 (2007) 18009-18017]. However, whether calcineurin plays a similar role in NK lytic granule release is not known. We tested whether calcineurin is involved in lytic granule exocytosis in human leukemic NK-92 cells using immunosuppressive drugs that block calcineurin function and by overexpressing a constitutively active calcineurin fusion protein. Our results indicate that calcineurin does play a role in lytic granule exocytosis in NK-92 cells, and suggest that, as was the case in TALL-104 cells, there are likely to be multiple calcium-dependent steps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.