ArticleMicrobes and infection2008
Host and microbiota factors that control Klebsiella pneumoniae mucosal colonization in mice.
Article in Microbes and infection, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Microbiome-mediated colonization resistance to carbapenem-resistant Klebsiella pneumoniae in ICU patients.NPJ biofilms and microbiomes · 2025Article
- Isolation, Characterization, and Anti-Biofilm Activity of a NovelAntibiotics (Basel, Switzerland) · 2025Article
- Deciphering the gastrointestinal carriage ofInfection and immunity · 2024Review
- Opportunistic Pathogens in Drinking Water Distribution Systems-A Review.Microorganisms · 2024Review
- Animal models ofFrontiers in microbiology · 2024Review
- Impact of childhood malnutrition and intestinal microbiota on MDR infections.JAC-antimicrobial resistance · 2023Review
- Proteomic Profiling of the Interplay Between a Bacterial Pathogen and Host Uncovers Novel Anti-Virulence Strategies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Efficacy ofJournal of microbiology and biotechnology · 2021Article
- FromMicroorganisms · 2021Review
- Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States.Scientific reports · 2021Article
- Animal Model To Study Klebsiella pneumoniae Gastrointestinal Colonization and Host-to-Host Transmission.Infection and immunity · 2020Article
- Antibiotic Resistance, Virulence Factors, Phenotyping, and Genotyping of Non-International journal of molecular sciences · 2020Article
- Commensal Bacteroidetes protect against Klebsiella pneumoniae colonization and transmission through IL-36 signalling.Nature microbiology · 2020Article
- Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.Scientific reports · 2019Article
- Characterization of multidrug-resistant Gram-negative bacilli isolated from hospitals effluents: first report of a blaBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Colonization, Infection, and the Accessory Genome ofFrontiers in cellular and infection microbiology · 2018Review
- Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide.International forum of allergy & rhinology · 2017Article
- A tale of two sites: how inflammation can reshape the microbiomes of the gut and lungs.Journal of leukocyte biology · 2016Review
- The human microbiota: novel targets for hospital-acquired infections and antibiotic resistance.Annals of epidemiology · 2016Review
- Genome Sequence of Klebsiella pneumoniae Respiratory Isolate IA565.Genome announcements · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Klebsiella pneumoniae is both an opportunistic pathogen and a commensal organism. We have previously reported that K. pneumoniae strain IA565 (KpIA565) is non-pathogenic in a murine model of acute pneumonia. In this study, KpIA565 was inoculated into wild-type mice and found to stably colonize and persist in the nasal cavity and gastrointestinal tract of mice for up to 3weeks post-inoculation. Intranasal inoculation of wild-type or germ-free mice with KpIA565 resulted in similar bacterial levels in the nasal cavity, suggesting KpIA565 nasal colonization is independent of normal nasal microbiota. In contrast, KpIA565 gastrointestinal tract colonization was significantly higher in germ-free mice than in wild-type mice, indicating that members of the endogenous microbiota regulate KpIA565 colonization. In the presence of non-specific dextran sodium sulfate-induced inflammation, KpIA565 gastrointestinal tract colonization was significantly higher when compared to non-DSS treated mice. Interestingly, KpIA565 colonization was unaffected by Citrobacter rodentium-induced gastrointestinal tract inflammation. However, gastrointestinal tract colonization with K. pneumoniae strain IA565 had no impact on the inflammatory histopathology in either colitis model. This study is the first to identify and describe mechanisms influencing the growth and behavior of a murine commensal strain of K. pneumoniae.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.