Evidence map›Paper›PMID 18762266›Full record

ReviewMicrobes and infection2008

Molecular and cellular mechanisms in the viral exacerbation of asthma.

Sharyn Tauro, Yung-Chang Su, Sandra Thomas, Jürgen Schwarze, Klaus I Matthaei, Dijana Townsend, Ljubov Simson, Ralph A Tripp, Suresh Mahalingam

Open access · greenAbstract readReview
In one paragraph

Review in Microbes and infection, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Sharyn TauroCentre for Biomolecular and Chemical Sciences, University of Canberra, Canberra, ACT 2601, Australia.
Yung-Chang Su
Sandra Thomas
Jürgen Schwarze
Klaus I Matthaei
Dijana Townsend
Ljubov Simson
Ralph A Tripp
Suresh Mahalingam
University of Canberra · AUAustralian National University · AUCentre for Inflammation Research · GBUniversity of Georgia · US

Funding

Wellcome TrustWellcome Trust 067454
6 · The paper itself

Abstract

The aetiology of asthma associated with viral infection is complex. The dynamics that contribute to disease pathogenesis are multifactorial and involve overlapping molecular and cellular mechanisms, particularly the immune response to respiratory virus infection or allergen sensitization. This review summarizes the evidence associated with factors that may contribute to the development or exacerbation of asthma including age, host factors, genetic polymorphisms, altered immune responses, and aspects of viral antigen expression. This review also provides an important perspective of key events linked to the development of asthmatic disease and related pulmonary inflammation from human and animal studies, and discusses their relationship as targets for disease intervention strategies.

Indexed as

AnimalsAsthmaDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHumansMaleNeural PathwaysPneumoniaRespiratory Tract InfectionsVirus DiseasesVirus Latency

Identifiers

PMID18762266
PMCPMC7172315
OpenAlexW2112173034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.