ArticleReproductive toxicology (Elmsford, N.Y.)2008
Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis.
Article in Reproductive toxicology (Elmsford, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Effects of perinatal exposure to endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents: a meta-analysis.Environmental science and pollution research international · 2022Pooled it
- Paternal Chronic Exposure to Copper Nanoparticles (CuNPs) Impairs Testicular Androgen and Estrogen Signalling in Adult Male Offspring in Mice.Biological trace element research · 2026Article
- Effect-Based Assessment of the Quality and Potential Presence of Hazardous Chemical Pollutants in Drinking and Potable Water in Mexico City.ACS ES&T water · 2026Article
- Sex- and Lineage-Dependent Transgenerational Effects of Vinclozolin and Flutamide on Rat Development and Behavior.Journal of the Endocrine Society · 2026Article
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Unfolding the complexity of epigenetics in male reproductive aging: a review of therapeutic implications.Molecular biology reports · 2024Review
- Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction.Cells · 2022Review
- Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria.Scientific reports · 2021Article
- Epigenetic transgenerational inheritance of testis pathology and Sertoli cell epimutations: generational origins of male infertility.Environmental epigenetics · 2019Article
- Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males.Scientific reports · 2018Article
- Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters.Endocrine connections · 2018Article
- Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny.Molecular psychiatry · 2017Article
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Environmentally Induced Epigenetic Transgenerational Inheritance of Reproductive Disease.Biology of reproduction · 2015Review
- Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance.Molecular and cellular endocrinology · 2014Review
- Early-life Exposure to Endocrine Disrupting Chemicals and Later-life Health Outcomes: An Epigenetic Bridge?Aging and disease · 2014Review
- Cryptic confounding compounds: A brief consideration of the influences of anthropogenic contaminants on courtship and mating behavior.Acta ethologica · 2013Article
- Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice.Biology of reproduction · 2013Article
- Epigenetic medicine and fetal alcohol spectrum disorders.Epigenomics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Exposure of gestating female rats to the anti-androgenic endocrine disruptor vinclozolin has been shown to induce transgenerational adult onset disease phenotypes. The current study, was designed to compare the actions of vinclozolin to the known anti-androgenic compound flutamide. The gestating female rats were exposed to intraperitoneal injections during embryonic day 8-14 (E8-E14) to 100mg/kg/day vinclozolin or flutamide at either 5mg or 20mg/kg/day. As previously observed, vinclozolin induced a transgenerational testis phenotype of increased spermatogenic cell apoptosis and decreased epididymal sperm number. In contrast, the flutamide exposures resulted in a testis phenotype of increased spermatogenic cell apoptosis and decreased epididymal sperm numbers in the F1 generation only, and not the F2 and F3 generation adult males. Interestingly, some of the low dose (5mg/kg) flutamide F2 generation offspring developed spinal agenesis and supernummery development (polymelia) of limbs. Although the actions of vinclozolin and flutamide appear similar in the F1 generation males, the transgenerational effects of vinclozolin do not appear to be acting through the same anti-androgenic mechanism as flutamide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.