ArticleLife sciences2008
Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase.
Article in Life sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review).International journal of molecular medicine · 2026Review
- Functions of Representative Terpenoids and Their Biosynthesis Mechanisms in Medicinal Plants.Biomolecules · 2023Review
- The Impact of Competitive Sports on Oral Health: Exploring Their Relationship with Salivary Oxidative Stress in Children.Healthcare (Basel, Switzerland) · 2023Article
- Possible mechanisms of treatment for spinal cord injury repair with tanshinone IIA.Frontiers in molecular neuroscience · 2023Article
- Effects of dietary pretreated Chinese herbal medicine supplementation on production performance, egg quality, uterine histopathological changes, and antioxidant capacity in late-phase laying hens.Frontiers in physiology · 2023Article
- Article
- Regulation of Nrf2 signaling pathway in heart failure: Role of extracellular vesicles and non-coding RNAs.Free radical biology & medicine · 2021Review
- Investigating the protective effect of tanshinone IIA against chondrocyte dedifferentiation: a combined molecular biology and network pharmacology approach.Annals of translational medicine · 2021Article
- Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis.Frontiers in pharmacology · 2021Review
- A Skin Lipidomics Study Reveals the Therapeutic Effects of Tanshinones in a Rat Model of Acne.Frontiers in pharmacology · 2021Article
- Article
- Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases.Drug design, development and therapy · 2020Review
- Medicinal Herbs Effective Against Atherosclerosis: Classification According to Mechanism of Action.Biomolecules & therapeutics · 2019Review
- Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics.Acta pharmacologica Sinica · 2018Review
- Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2-Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action.Oxidative medicine and cellular longevity · 2018Review
- Crosstalk between Beclin-1-dependent autophagy and caspase‑dependent apoptosis induced by tanshinone IIA in human osteosarcoma MG-63 cells.Oncology reports · 2016Article
- Recent insights into the biological activities and drug delivery systems of tanshinones.International journal of nanomedicine · 2016Review
- Sodium tanshinone IIA sulfonate suppresses pulmonary fibroblast proliferation and activation induced by silica: role of the Nrf2/Trx pathway.Toxicology research · 2016Article
- Chinese Herbal Compounds for the Prevention and Treatment of Atherosclerosis: Experimental Evidence and Mechanisms.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Tanshinone IIA induces apoptosis in human oral cancer KB cells through a mitochondria-dependent pathway.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimsTanshinone IIA is an important ingredient in the herb danshen (Salvia miltiorrhiza), which has been used to treat cardiovascular diseases such as atherosclerosis and angina for hundreds of years in China. There are numerous reports that TIIA has anti-oxidant properties but the chemical structure indicates that TIIA is fully oxidized. Here, we test the hypothesis that TIIA alters the expression and/or activity of specific anti-oxidation enzymes to protect cells from oxidant damage. MAIN
methodsWe utilized J774 macrophages to model cellular responses to TIIA when challenged with H(2)O(2). Expression and activity levels of several anti-oxidation enzymes were investigated and the only system modulated by TIIA was glutathione peroxidase (GPx). KEY
findingsGPx-1 mRNA levels were significantly increased by TIIA but not the vitamin E analogue, Trolox. GPx activities were also significantly increased by TIIA. Mercaptosuccinic acid inhibited GPx activity and the protective effect of TIIA was attenuated. Thus, TIIA protects cultured macrophages from H(2)O(2)-induced cell death and protection is mediated in large part by TIIA induction of GPx gene expression and activity. SIGNIFICANCE: Because of the importance of GPx in health and because TIIA is able to modulate GPx activity to some extent in cell culture, we suggest that TIIA is a worthwhile candidate for further study in animal models of atherosclerosis and eventually in human prospective trials.
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