ArticleJournal of experimental & clinical cancer research : CR2008
Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin.
Article in Journal of experimental & clinical cancer research : CR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Multiple recurrent follicular dendritic cell sarcoma: A case report.Molecular and clinical oncology · 2020Article
- Follicular dendritic cell sarcoma of the head and neck: Case report, literature review, and pooled analysis of 97 cases.Head & neck · 2016Review
- A rare case of follicular dendritic cell sarcoma with pseudochylous effusion and review of literature from India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2015Article
- Inoperable inflammatory myofibroblastic tumour of the para-nasal sinuses and orbit with recurrence responding to methotrexate and prednisolone: a case report.BMC research notes · 2015Article
- Follicular dendritic cell sarcoma of the stomach: case report and review of the literature.Current oncology (Toronto, Ont.) · 2014Article
- Dendritic cell tumor in a salivary gland lymph node: a rare differential diagnosis of salivary gland neoplasms.Diagnostic pathology · 2011Article
- Fine-Needle Aspiration Cytology of Follicular Dendritic Cell Sarcoma of Cervical Lymph Node: A Challenging Diagnosis.Journal of microscopy and ultrastructureArticle
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFollicular dendritic cell (FDC) sarcoma is a rare neoplasm arising in lymph nodes but also in extranodal sites from accessory cells of the immune system that are essential for the function of antigen presentation and germinal center reaction regulation. FDC sarcoma has a significant recurrent and metastatic potential and for these reason it should be viewed as an intermediate grade malignancy.
methodsWe report the case of a 49-year old woman patient who showed persistent, enlarged, hard, cervical lymph node. The most common histologic feature was the presence of oval to spindle cells with elongated nuclei, vesicular or stippled chromatin and scant eosinophilic cytoplasm. Immunohistochemically, tumor cells were diffusely positive for follicular dendritic cell markers CD21, CD23 and negative for cytokeratin.The patient after complete excision of the lymph node underwent five courses of adjuvant chemotherapy with COP plus PEG-liposomal doxorubicin, considering the propensity of the tumor to metastasize.
resultsNo hematological or cardiac toxicity were registered and among the other extra hematological effects only transitory palmar erythrodysesthesia is worthy of mention. After a follow up of 5 years the patient is alive and in CR.
conclusionThese results suggest that this therapeutic modality may be useful in the management of FDC sarcoma.
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Registered trials
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