ArticleJournal of thrombosis and haemostasis : JTH2008
Evolution of the contact phase of vertebrate blood coagulation.
Article in Journal of thrombosis and haemostasis : JTH, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 125 citations in OpenAlex.
- Structural insights into the exosite-mediated activation of factor IX by factor XIa using cryogenic electron microscopy.Journal of thrombosis and haemostasis : JTH · 2026Article
- Standardization of coagulometric tests in griffon vultures (Frontiers in veterinary science · 2026Article
- Crystal structure of coagulation factor XII N-terminal domains 1-5.Acta crystallographica. Section D, Structural biology · 2025Article
- High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases.Protein science : a publication of the Protein Society · 2025Article
- Factor XII Structure-Function Relationships.Seminars in thrombosis and hemostasis · 2024Review
- Plasma kallikrein supports FXII-independent thrombin generation in mouse whole blood.Blood advances · 2024Article
- The Clot Thickens: Differential Coagulotoxic and Cardiotoxic Activities of Anguimorpha Lizard Venoms.Toxins · 2024Article
- Super-high procoagulant activity of gecko thrombin: A gift from sky dragon.CNS neuroscience & therapeutics · 2023Article
- Discovery of Teleost Plasma Kallikrein/Coagulation Factor XI-Like Gene from Channel Catfish (Ictalurus punctatus) and the Evidence that the Protein Encoded by it Acts as a Lectin.Journal of molecular evolution · 2023Article
- Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond.Frontiers in physiology · 2023Review
- Glassfrogs conceal blood in their liver to maintain transparency.Science (New York, N.Y.) · 2022Article
- Comparative sequence analysis of vitamin K-dependent coagulation factors.Journal of thrombosis and haemostasis : JTH · 2022Article
- Domain Evolution of Vertebrate Blood Coagulation Cascade Proteins.Journal of molecular evolution · 2022Article
- Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains.Blood advances · 2022Article
- High Molecular Weight Kininogen: A Review of the Structural Literature.International journal of molecular sciences · 2021Review
- Role of ribosomal RNA released from red cells in blood coagulation in zebrafish and humans.Blood advances · 2021Article
- ptFVa (Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Molecular evolution of kalliklectin in teleost and identification of the novel type with eight apple domains in channel catfish, Ictalurus punctatus.Molecular biology reports · 2021Article
- Development of Coagulation Factor XII Antibodies for Inhibiting Vascular Device-Related Thrombosis.Cellular and molecular bioengineering · 2021Article
- Proteolytic activity of contact factor zymogens.Journal of thrombosis and haemostasis : JTH · 2021Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious reports have noted that factor (F) XI and FXII and prekallikrein (the contact phase proteases) are absent in fish.
objectivesA broad survey of recently completed genomes was undertaken to find where during the course of vertebrate evolution these coagulation factors appeared.
methodsBLAST searches were conducted for the various factors on genomes of lamprey, puffer fish, zebra fish, frog, chicken, platypus, and opossum.
resultsIt was confirmed that FXII is absent from fish; it is present in frog, platypus, and opossum, but is absent in chicken, an apparent example of gene loss. A single gene corresponding to the evolutionary predecessor of FXI and prekallikrein occurs in frog, chicken, and platypus. The opossum (a marsupial) has both prekallikrein and FXI, completing the full complement of these genes that occurs in eutherian mammals.
conclusionsThe step-by-step accrual of genes for these factors by a series of timely gene duplications has been confirmed by phylogenetic analysis and other considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.