ArticleMolecular microbiology2008
Calcium efflux is essential for bacterial survival in the eukaryotic host.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 91 citations in OpenAlex.
- The calcium signal regulatory network and the roles of calcium-binding proteins in bacteria.World journal of microbiology & biotechnology · 2026Review
- Ionomycin Exhibits Potent and Selective Bactericidal Activity Against Clostridioides difficile Through Calcium-Dependent Membrane Disruption.MicrobiologyOpen · 2026Article
- Decoding the functional role of the calcium ATPase YloB in microbially induced calcite precipitation and sporulation inMicrobiology (Reading, England) · 2026Article
- Potassium-Doped MnOACS nano · 2025Article
- Dephosphorylation and ion binding in prokaryotic calcium transport.Science advances · 2024Article
- Calcium RescuesMicroorganisms · 2024Article
- Determinants of bacterial survival and proliferation in blood.FEMS microbiology reviews · 2024Review
- Unveiling the Secrets of Calcium-Dependent Proteins in Plant Growth-Promoting Rhizobacteria: An Abundance of Discoveries Awaits.Plants (Basel, Switzerland) · 2023Review
- CaCommunications biology · 2023Article
- The role of CopA in Streptococcus pyogenes copper homeostasis and virulence.Journal of inorganic biochemistry · 2023Article
- The Activity of Calcium Glycerophosphate and Fluoride against Cariogenic Biofilms ofAntibiotics (Basel, Switzerland) · 2023Article
- Effect of membrane depolarization against Aspergillus niger GM31 resistant by ultra nanoclusters characterized by AgScientific reports · 2023Article
- The elements of life: A biocentric tour of the periodic table.Advances in microbial physiology · 2023Article
- Phenotypic and Genotypic Characterization of Multidrug-Resistant Enterobacter hormaechei CarryingMicrobiology spectrum · 2022Article
- TheInternational journal of molecular sciences · 2022Article
- Machine Learning Establishes Single-Cell Calcium Dynamics as an Early Indicator of Antibiotic Response.Microorganisms · 2021Article
- Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq.Cell host & microbe · 2021Article
- Genome-Wide Functional Screen for Calcium Transients in Escherichia coli Identifies Increased Membrane Potential Adaptation to Persistent DNA Damage.Journal of bacteriology · 2021Article
- Setting the Stage: Genes Controlling Mechanosensation and CaJournal of bacteriology · 2021Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In dynamic environments, intracellular homeostasis is maintained by transport systems found in all cells. While bacterial influx systems for essential trace cations are known to contribute to pathogenesis, efflux systems have been characterized mainly in contaminated environmental sites. We describe that the high calcium concentrations in the normal human host were toxic to pneumococci and that bacterial survival in vivo depended on CaxP, the first Ca2+ exporter reported in bacteria. CaxP homologues were found in the eukaryotic sacroplasmic reticulum and in many bacterial genomes. A caxP- mutant accumulated intracellular calcium, a state that was used to reveal signalling networks responsive to changes in intracellular calcium concentration. Chemical inhibition of CaxP was bacteriostatic in physiological calcium concentrations, suggesting a new antibiotic target uncovered under conditions in the eukaryotic host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.