ArticleMolecular microbiology2008
Cross-talk suppression between the CpxA-CpxR and EnvZ-OmpR two-component systems in E. coli.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Regulation of the Yersinia pseudotuberculosis Type III Secretion System by the CpxAR Two-Component System.Molecular microbiology · 2026Article
- Elucidating the mechanism of thiosulfate oxidation by a novel two-component system SulRS in deep-seaiScience · 2026Article
- Multiple input-multiple output (MIMO) designs in two-component signalling systems of Mycobacterium tuberculosis.FEMS microbiology reviews · 2026Review
- CpxR and LrhA coordinate the regulation of Xenocoumacin 1 biosynthesis, flagellar assembly, and chemotaxis inFrontiers in microbiology · 2026Article
- Two-Component Systems inVeterinary sciences · 2025Review
- AProceedings of the National Academy of Sciences of the United States of America · 2025Article
- OmpR Indirectly Regulates Biosynthesis of Xenocoumacin 1 inMicroorganisms · 2025Article
- Functional and Pangenomic Exploration of Roc Two-Component Regulatory Systems Identifies Novel Players Across Pseudomonas Species.Molecular microbiology · 2025Article
- Determining the potential targets of silybin by molecular docking and its antibacterial functions on efflux pumps and porins in uropathogenic E. coli.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Regulatory role of the Cpx ESR in bacterial behaviours.Virulence · 2024Review
- The two-component system CpxA/CpxR regulates pathogenesis and stress adaptability in the poplar canker bacterium Lonsdalea populi.Molecular plant pathology · 2024Article
- Development of a two component system based biosensor with high sensitivity for the detection of copper ions.Communications biology · 2024Article
- Cross-regulation and cross-talk of conserved and accessory two-component regulatory systems orchestrate Pseudomonas copper resistance.PLoS genetics · 2024Article
- Crosstalk involving two-component systems inJournal of bacteriology · 2024Review
- Enhancing Benzo[a]pyrene Degradation byMicroorganisms · 2024Article
- Cross-Phosphorylation between AgrC Histidine Kinase and the Noncognate Response Regulator Lmo1172 inMicroorganisms · 2024Article
- Marginal specificity in protein interactions constrains evolution of a paralogous family.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Dietary Source of High Level of Fluoroquinolone Tolerance inResearch (Washington, D.C.) · 2023Article
- Genomic analysis and chitinase characterization ofFrontiers in microbiology · 2023Article
- Exploring Cluster-Dependent Antibacterial Activities and Resistance Pathways of NOSO-502 and Colistin against Enterobacter cloacae Complex Species.Antimicrobial agents and chemotherapy · 2022Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
Many bacteria possess large numbers of two-component signalling systems, which are composed of histidine kinase-response regulator pairs. The high level of sequence similarity between some systems raises the possibility of undesired cross-talk between a histidine kinase and a non-cognate response regulator. Although molecular specificity ensures that phospho-transfer occurs primarily between correct partners, even a low level of inappropriate cross-talk could lead to unacceptable levels of noise or interference in signal transduction. To explore mechanisms that provide insulation against such interference, we have examined cross-talk between the histidine kinase CpxA and non-cognate response regulator OmpR in Escherichia coli. Our results show that there are two mechanisms that suppress cross-talk between these two proteins, which depend on the corresponding cognate partners CpxR and EnvZ and on the bifunctional nature of the histidine kinases CpxA and EnvZ. When cross-talk is detectable, we find it is independent of CpxA stimulus. We also show that cross-talk suppression leads to mutational robustness, i.e. it masks the effects of mutations that would otherwise lead to increased cross-talk. The mechanisms that provide insulation against interference described here may be applicable to many other two-component systems.
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