ArticleMitochondrion2008
Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse.
Article in Mitochondrion, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mitochondrial transfer technologies with molecular insights into clinical applications.Stem cells (Dayton, Ohio) · 2026Review
- Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Modulating Cellular Responses to Mechanical Forces to Promote Wound Regeneration.Advances in wound care · 2022Review
- Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice.Scientific reports · 2018Article
- Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing.Cell reports · 2017Article
- Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRL/MpJ mouse.BMC genomics · 2015Article
- Successful metabolic adaptations leading to the prevention of high fat diet-induced murine cardiac remodeling.Cardiovascular diabetology · 2015Article
- From Immunity and Vaccines to Mammalian Regeneration.The Journal of infectious diseases · 2015Article
- Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.Heredity · 2014Article
- Increased AMP-activated protein kinase in skeletal muscles of Murphy Roth Large mice and its potential role in altered metabolism.Physiological reports · 2014Article
- Dugesia sicula (Platyhelminthes, Tricladida): the colonizing success of an asexual Planarian.BMC evolutionary biology · 2013Article
- Heteroplasmy in the mitochondrial genomes of human lice and ticks revealed by high throughput sequencing.PloS one · 2013Article
- The super super-healing MRL mouse strain.Frontiers in biology · 2012Article
- Vector blood meals and Chagas disease transmission potential, United States.Emerging infectious diseases · 2012Article
- The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.Cell metabolism · 2010Article
- Mitochondrial DNA heteroplasmy in Candida glabrata after mitochondrial transformation.Eukaryotic cell · 2010Article
- Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection.Biomarker insights · 2009Article
- Retained features of embryonic metabolism in the adult MRL mouse.Molecular genetics and metabolism · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The MRL/MpJ mouse is an inbred laboratory strain of Mus musculus, known to exhibit enhanced autoimmunity, increased wound healing, and increased regeneration properties. We report the full-length mitochondrial DNA (mtDNA) sequence of the MRL mouse (Accession # EU450583), and characterize the discovery of two naturally occurring heteroplasmic sites. The first is a T3900C substitution in the TPsiC loop of the tRNA methionine gene (tRNA-Met; mt-Tm). The second is a heteroplasmic insertion of 1-6 adenine nucleotides in the A-tract of the tRNA arginine gene (tRNA-Arg; mt-Tr) at positions 9821-9826. The level of heteroplasmy varied independently at these two sites in MRL individuals. The length of the tRNA-Arg A-tract increased with age, but heteroplasmy at the tRNA-Met site did not change with age. The finding of naturally occurring mtDNA heteroplasmy in an inbred strain of mouse makes the MRL mouse a powerful new experimental model for studies designed to explore therapeutic measures to alter the cellular burden of heteroplasmy.
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