ReviewNeuron2008
Making an effort to listen: mechanical amplification in the ear.
Review in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
169 citing papers in PubMed.
- A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells.bioRxiv : the preprint server for biology · 2026Article
- Optical imaging of subcellular fluctuations within hair cells.Biophysical reports · 2026Article
- The bidirectional interplay between RNA processing and mechanotransduction.Cell reports · 2025Review
- Effect of Sound Amplification on Central Auditory Plasticity: Endbulb of Held as a Substrate.Brain sciences · 2025Article
- Two-tone suppression between the ultrasounds above and within the hearing range in mice.Experimental physiology · 2025Article
- Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Influence of Myosin Regulatory Light Chain and Myosin Light Chain Kinase on the Physiological Function of Inner Ear Hair Cells.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Hearing restoration through hair cell regeneration: A review of recent advancements and current limitations.Hearing research · 2025Review
- Auditory cellular cooperativity probed via spontaneous otoacoustic emissions.Biophysical journal · 2025Article
- Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells.bioRxiv : the preprint server for biology · 2024Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Neural control and innate self-tuning of the hair cell's active process.Biophysical journal · 2024Article
- Nanomechanics of wild-type and mutant dimers of the inner-ear tip-link protein protocadherin 15.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Transient Receptor Potential (TRP) Channels in Cochlear Function: Looking Beyond Mechanotransduction.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Conditions Underlying the Appearance of Spontaneous Otoacoustic Emissions in Mammals.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- Article
- Criticality and chaos in auditory and vestibular sensing.Scientific reports · 2024Article
- Review of chaos in hair-cell dynamics.Frontiers in neurology · 2024Review
- The Dual Roles of Triiodothyronine in Regulating the Morphology of Hair Cells and Supporting Cells during Critical Periods of Mouse Cochlear Development.International journal of molecular sciences · 2023Article
109 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The inner ear's performance is greatly enhanced by an active process defined by four features: amplification, frequency selectivity, compressive nonlinearity, and spontaneous otoacoustic emission. These characteristics emerge naturally if the mechanoelectrical transduction process operates near a dynamical instability, the Hopf bifurcation, whose mathematical properties account for specific aspects of our hearing. The active process of nonmammalian tetrapods depends upon active hair-bundle motility, which emerges from the interaction of negative hair-bundle stiffness and myosin-based adaptation motors. Taken together, these phenomena explain the four characteristics of the ear's active process. In the high-frequency region of the mammalian cochlea, the active process is dominated instead by the phenomenon of electromotility, in which the cell bodies of outer hair cells extend and contract as the protein prestin alters its membrane surface area in response to changes in membrane potential.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.